甲状旁腺腺瘤负荷与生化指标间相关性分析

Correlation analysis between tumor burden and biochemical indicators of parathyroid adenoma

目的确定甲状旁腺腺瘤(parathyroid adenoma,PA)肿瘤体积和重量与患者生化指标等临床特征的相关性。方法卡前瞻性电子数据库收集2021年10月至2023年10月于中国医学科学院北京协和医院基本外科初次手术治疗的208例PA患者的临床资料,包括年龄、性别、血清甲状旁腺激素(parathyroid hor-mone,PTH)、钙等生化指标及肿瘤体积和重量,利用斯皮尔曼相关性分析各生化指标与肿瘤体积和重量的关系。结果PA的肿瘤体积和重量分别与患者血清PTH(r=0.33,P<0.001;r=0.39,P<0.001)、钙(r=0.16,P=0.018;r=0.18,P=0.007)和碱性磷酸酶(r=0.24,P<0.001;r=0.27,P<0.001)水平呈正相关。多因素分析发现,影响PTH的临床相关因素有年龄、血钙和肿瘤重量(F=30.325,P<0.001)。结论PA患者的肿瘤负荷与部分实验室生化参数相关。年龄、肿瘤囊性变可能影响患者血清PTH水平。

Objective To determine the correlation of tumor volume and weight with biochemical parame-ters in patients with parathyroid adenoma(PA).Methods A prospective electronic database collected clinical da-ta on 208 patients with PA treated for the first time by surgery at department of general surgery,Peking Union Medi-cal College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College.The relationship be-tween biochemical parameters and tumor volume and weight was analyzed with Spearman's correlation.Results Tumor volume and weight were positively correlated with parathyroid hormone(PTH)(r=0.33,P<0.001;r=0.39,P<0.001),calcium(r=0.16,P=0.018;r=0.18,P=0.007)and alkaline phosphatase levels(r=0.24,P<0.001;r=0.27,P<0.001),respectively.Clinical correlates affecting serum PTH were age,serum calcium and tumor weight(F=30.325,P<0.001).Conclusions Tumor burden in patients with PA correlates with some laboratory biochemical parameters.Age and cystic lesions of the tumor may influence the actual serum PTH levels.