康复新液联合奥美拉唑治疗早期胃癌胃黏膜剥离术后并发症临床观察

Therapeutic effect of Kangfuxin Liquid combined with omeprazole in treatment of complications after gastric mucosal dissection in early gastric cancer

目的观察康复新液+奥美拉唑治疗早期胃癌胃黏膜剥离术(ESD)后并发症临床观察。方法将我院108例早期胃癌患者随机为治疗组与对照组各54例。两组行ESD治疗,对照组服用奥美拉唑治疗,治疗组服用康复新液+奥美拉唑。比较两组总有效率、创面愈合和住院时间、溃疡面积、血管内皮生长因子(VEGF)、中医证候积分、溃疡愈合情况及并发症。结果治疗后,治疗组总有效率高于对照组(P<0.05);治疗组创面愈合和住院时间少于对照组(P<0.05);两组溃疡面积、中医证候积分低于治疗前,VEGF高于治疗前,治疗组溃疡面积、中医证候积分低于对照组,VEGF高于对照组(P<0.05);两组溃疡愈合情况优于治疗前,治疗组溃疡愈合情况优于对照组(P<0.05);治疗组并发症发生率低于对照组(P<0.05)。结论康复新液联合奥美拉唑治疗早期胃癌ESD后患者疗效好,能促进溃疡愈合,减少并发症。

Objective To observe the therapeutic effect of Kangfuxin Liquid combrned with omeprazole in treatment of complications after gastric mucosal dissection(ESD)for early gastric cancer.Methods A total of 108 patients with early gastric cancer were randomly divided into treatment group and control group,with 54 cases in each group.Both groups were treated with ESD,while control group was treated with omeprazole,treatment group was treated with Kangfuxin Liquid and omeprazole.The total effective rate,wound healing and hospitalization time,ulcer area,vascular endothelial growth factor(VEGF),TCM syndrome score,ulcer healing status,and complications were compared between the two groups.Results After treatment,the total effective rate of treatment group was higher than that of control group(P<0.05);the wound healing,hospitalization time,and complications in treatment group were less than those in control group(P<0.05),and were lower in treatment group than control group;the ulcer area and TCM syndrome score were lower than before treatment,and were lower in treatment group than control group(P<0.05),while VEGF was higher,and was higher in treatment group than control group(P<0.05);the healing of ulcers in both groups was better than before treatment,and was better in treatment group than control group(P<0.05);the occurance of complications in observation group was lower than control group(P<0.05).Conclusion Kangfuxin liquid combined with omeprazole is effective in treating early gastric cancer with ESD,promoting ulcer healing and reducing complications.