太极拳运动对中老年无症状脑梗死患者NO、ET-1及hs-CRP的影响

Effect of tai chi on NO,ET-1 and hs-CRP in middle-aged and elderly patients with asymptomatic cerebral infarction

目的观察太极拳运动对无症状脑梗死(SBI)患者一氧化氮(NO)、内皮素-1(ET-1)、超敏C反应蛋白(hs-CRP)水平的影响。方法选取2021年3月至2022年3月于福建中医药大学附属第二人民医院健康管理中心(治未病)诊断为无症状脑梗死的患者147例。随机分为健康宣教组、太极拳组和快步走组三组,每组49例。健康宣教组给予无症状脑梗死相关知识的健康宣教,太极拳组和快步走组在健康宣教组的基础上,分别进行24式简化太极拳训练和快步走训练,每周3次,每次60分钟,连续训练12周。12周后观察三组患者干预前后NO、ET-1、hs-CRP水平。结果①重复测量方差分析结果显示,三组患者的NO的时间效应、组间效应和交互效应差异均具有统计学意义(P<0.05);三组患者的ET-1的时间效应和交互效应均具有统计学意义(P<0.05),组间效应差异均无统计学意义(P>0.05);三组患者的hs-CRP的时间效应、组间效应和交互效应差异均无统计学意义(P>0.05)。②干预前后组内与干预前比较,太极拳组干预后NO水平上升,ET-1及hs-CRP水平下降;快步走组ET-1水平下降,差异有统计学意义(P<0.05)。③干预后组间比较结果显示,太极拳组干预后的NO水平高于快步走组和健康宣教组,差异有统计学意义(P<0.05);健康宣教组干预后的ET-1水平高于太极拳组和快步走组,差异有统计学意义(P<0.05);太极拳组干预后的hs-CRP水平低于快步走组,差异有统计学意义(P<0.05)。结论太极拳运动可增加无症状脑梗死患者NO合成及降低ET-1、hs-CRP释放。

Objective To observe the effect of Tai Chi exercise on the levels of nitric oxide(NO),endothelin-1(ET-1)and high-sensitivity C-reactive protein(hs-CRP)in patients with asymptomatic cerebral infarction(SBI).Methods From March 2021 to May 2023,147 patients diagnosed with SBI in the Health Management Center(Preventive Treatment of Disease)of the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine were selected.They were randomly divided into 3 groups,49 cases in each group.The health education group was given health education on SBI-related knowledge.On the basis of the health education group,the Tai Chi group and the brisk walking group were given 24-style simplified Tai Chi training and brisk walking training respectively,3 times a week,60 minutes each time,for 12 weeks.After 12 weeks,the levels of NO,ET-1 and hs-CRP in the three groups were observed before and after intervention.Results①The results of repeated measures analysis of variance showed that the time effect,inter-group effect and interaction effect of NO in the three groups were statistically significant(P<0.05).The time effect and interaction effect of ET-1 in the three groups were statistically significant(P<0.05),and there was no significant difference between the groups(P>0.05).There was no significant difference in the time effect,inter-group effect and interaction effect of hs-CRP among the three groups(P>0.05).②Compared with before intervention,the level of NO in the Taichi group increased after intervention,and the levels of ET-1 and hs-CRP decreased.The level of ET-1 in the brisk walking group decreased,and the difference was statistically significant(P<0.05).③The results of comparison between groups after intervention showed that the NO level after intervention in the Taichi group was higher than that in the brisk walking group and the health education group,and the difference was statistically significant(P<0.05).The level of ET-1 in the health education group after intervention was higher than that in the Taichi group and the brisk walking group(P<0.05).The hs-CRP level after intervention in the Taichi group was lower than that in the brisk walking group,and the difference was statistically significant(P<0.05).Conclusion Taichi can increase NO synthesis and reduce the release of ET-1 and hs-CRP in patients with SBI.