肌少症与心血管疾病相关性的研究进展

Research progress on sarcopenia and cardiovascular disease

肌少症是一种与年龄相关的临床综合征,主要特征是骨骼肌质量、力量和身体功能的下降,可能导致一系列不良健康结局,例如虚弱、跌倒、骨折、住院和死亡等风险增加。越来越多的研究表明,在心血管疾病患者中肌少症的患病率更高,这两种疾病之间可能通过炎症、胰岛素抵抗、氧化应激和线粒体功能障碍等机制相互作用,增加不良结局的风险。因此,本综述对肌少症和心血管疾病的相关研究进行归纳和总结,阐述肌少症与心血管疾病的流行病学特征、潜在关系和机制、预防和干预措施,并鼓励早期筛查,为肌少症与心血管疾病的多学科综合管理提供新策略和方法。

Sarcopenia is an age-related clinical syndrome characterized by a decline in muscle mass,strength,and physical performance,which may lead to a range of adverse health outcomes such as increased risk of frailty,falls,fractures,hospitalization and mortality.Increasing evidence suggests a higher prevalence of sarcopenia in cardiovascular disease patients,and these two conditions may interact through mechanisms such as inflammation,insulin resistance,oxidative stress,and mitochondrial dysfunction,increasing the risk of adverse outcomes.Therefore,the purpose of this review is to summarize and synthesize the relevant research on sarcopenia and cardiovascular diseases,further elucidating their epidemiological characteristics,underlying relationships and mechanisms,prevention and intervention measures,and advocating for early screening,providing new strategies and approaches for the multidisciplinary management of sarcopenia and cardiovascular diseases.