CBIT联合盐酸硫必利治疗抽动障碍患儿临床效果及其对生活质量的影响

Clinical efficacy of CBIT combined with tiapride hydrochloride in the treatment of children with tic disorder and its influence on quality of life

目的 探讨综合行为干预疗法(CBIT)联合盐酸硫必利治疗抽动障碍(TD)患儿的临床效果及其对生活质量的影响。方法 将90例TD患儿按照随机数字表法分为研究组、对照1组、对照2组,每组30例。对照1组患儿给予盐酸硫必利治疗,对照2组患儿给予CBIT训练治疗,研究组患儿给予CBIT训练联合盐酸硫必利治疗。比较三组患儿耶鲁综合抽动严重程度量表(YGTSS)、注意力缺陷多动障碍评定量表(SNAP-IV)、儿童耶鲁-布朗强迫症量表(CY-BOCS)、儿童生活质量量表(PedsQL)、临床总体印象改善量表(CGI-I)评分、临床疗效和不良反应情况。结果研究组患儿治疗总有效率高于对照1组、对照2组(P<0.05)。治疗3个月末,三组患儿YGTSS、SNAP-IV、CY-BOCS评分均较治疗前降低,且研究组低于对照1组、对照2组(P<0.01)。治疗3个月末,三组患儿PedsQL评分均较治疗前升高,且研究组高于对照1组、对照2组(P<0.01)。治疗3个月末,研究组患儿CGI-I评分低于对照1组、2组(P<0.01)。三组患儿不良反应总发生率无明显差异(P>0.05)。结论 CBIT训练联合盐酸硫必利治疗对TD患儿的临床疗效确切,可改善抽动、多动、强迫症状,提高生活质量,改善临床总体印象,且安全性较好。

Objective To explore the clinical efficacy of comprehensive behavioral intervention therapy(CBIT) combined with tiapride hydrochloride in the treatment of children with tic disorder(TD) and its influence on quality of life.Methods Ninety TD children were divided into research group,control group 1,and control group 2 with 30 cases in each according to the random number table.Control group 1 received thiopril hydrochloride treatment,control group 2 did the CBIT,and research group did CBIT combined with thiopril hydrochloride.The scores on the Yale Global Tic Severity Scale(YGTSS),the Swanson,Nolan,and Pelham IV Rating Scale(SNAP-IV),Children's Yale-Brown Obsessive-Compulsive Scale(CY-BOCS),Pediatric Quality of Life Inventory(PedsQL),and Clinical Global Impression-Improvement(CGI-I) as well as clinical efficacy and adverse reactions were compared among three groups.Results The total effective rate was higher in research than control group 1 and 2(P<0.05).At the end of 3 month treatment scores on the YGTSS,SNAP-IV,and CY-BOCS of three groups lowered compared with pretreatment and were lower in research than control group 1 and 2(P<0.01).At the end of 3 month treatment the PedsQL scores of three groups elevated compared with pre-treatment and that was higher in research than control group 1 and 2(P<0.01).At the end of 3 month treatment the CGI-I score was lower in research than control group 1 and 2(P<0.01).There was no significant difference in the total incidence of adverse reactions among the three groups(P>0.05).Conclusion CBIT training combined with tiapride hydrochloride has a definite clinical effect in the t reat ment of TD ch ild ren,ca n improve t witch,hyperactivity and obsessive-compulsive symptoms,quality of life and clinical global impression,and has high safety.