摘要
近年来免疫系统被认为与阿尔茨海默病(AD)的发生发展密切相关,全基因组关联研究目前已确定了许多与免疫反应、小胶质细胞相关的AD风险基因。本文现以免疫相关的AD风险基因为对象,围绕其生物学功能及在AD中的可能作用进行综述,以期为AD的早期防治提供新的科学依据。
Immune system is thought to be closely associated with Alzheimer's disease(AD)in recent years.Genome-wide association studies have identified many AD risk genes related to immune response and microglia.This paper mainly reviews immune-related AD risk genes,describing their biological functions and possible roles in AD,in order to provide new scientific basis for early prevention and treatment of AD.
作者
贾丽娜
朱晓峰
尹昌浩
Jia Lina;Zhu Xiaofeng;Yin Changhao(Graduate School of Mudanjiang Medical College,Mudanjiang 157011,China;Department of Neurology,Red Flag Hospital Affiliated to Mudanjiang Medical College,Heilongjiang Provincial Key Laboratory of Ischemic Stroke Prevention and Treatment,Mudanjiang 157011,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2024年第1期78-82,共5页
Chinese Journal of Neuromedicine
基金
黑龙江省省属高校基本科研费科研项目(2019-KYYWFMF-0029)。
