干细胞在癫痫及癫痫神经精神共患病治疗中的研究进展

Recent advance in stem cell therapy for epilepsy and epileptic neuropsychiatric comorbidity

癫痫是常见的神经系统疾病之一,患者通常伴随有焦虑、抑郁、认知障碍等神经精神共患病。目前的治疗方法对于存在药物耐受或伴有神经精神共患病的患者疗效欠佳,因此寻找新的治疗方法十分必要。干细胞因其自我更新、多向分化,存在于多种组织中并可参与组织再生与修复的特性,在癫痫治疗中具备较好的应用基础。本文现围绕干细胞在癫痫及癫痫神经精神共患病治疗中的研究进展进行综述,以期为后续干细胞在该领域的临床应用提供参考。

Epilepsy,one of the most common neurological diseases,is usually accompanied by anxiety,depression,cognitive disorders and other neuropsychiatric comorbidities.Current therapies are not effective in patients with drug-resistant and psychoneurotic comorbidities,so it is necessary to find new therapeutic approaches to address this challenge.Stem cells have good application basis in epilepsy for their characteristics of self-renewal,multidirectional differentiation,existence in a variety of tissues,participating in tissue regeneration and repair.This review focuses on the research progress of stem cells in epilepsy and epileptic neuropsychiatric comorbidity,in order to provide some references for subsequent clinical application in this field.