基于数据挖掘的降尿酸中药复方用药规律分析

Analysis of the Medication Rules of Traditional Chinese Medicine Formulae for Reducing Uric Acid Based on Data Mining

目的:基于数据挖掘,以临床观察及动物实验文献研究为切入点,分析降尿酸中药复方的用药特点和组方规律,为高尿酸血症和痛风的中医临床治疗提供参考和借鉴,为降尿酸新药的研发提供依据。方法:检索国家知识基础设施数据库、中国学术期刊数据库、中文科技期刊数据库中关于中药复方降尿酸的文献研究,构建方药数据库,运用软件统计中药频次、性味和功效,并进行关联规则分析、聚类分析。结果:共纳入57个中药复方,涉及174味中药,其中27味中药使用频次>3次。常用类型以清热药、补虚药、利水渗湿药等为主。聚类分析得到3个核心组方,以健脾祛湿、清热活血为主。关联规则分析共得到4个药对、16个三味药药组、4个四味药药组,其中苍术-黄柏支持度最高,是降尿酸的核心药对。结论:中药降尿酸用药以清热利湿、活血化瘀为主,辅以健脾祛湿、补中益气,体现“标本兼顾”的中医药治疗原则,为临床提高疗效及新药的开发提供参考依据。

Objective:Based on data mining,clinical observation and animal experimental literature research were employed as the entry point to analyze the characteristics and prescription rules of traditional Chinese medicine formulae in the treatment of gout and hyperuricemia.The aim of this study was to provide reference for the clinical treatment of gout and hyperuricemia with traditional Chinese medicine and serve as a basis for the development of new drugs for reducing uric acid.Methods:The literature studies on traditional Chinese medicine formulas for lowering uric acid were retrieved from the China National Knowledge Infrastructure(CNKI),China Science Periodical Database(CSPD),Chinese Citation Database(CCD),and the prescription database was constructed.The frequency,flavor and efficacy of traditional Chinese medicine were calculated using software,and association rule analysis and cluster analysis were performed.Results:A total of 57 traditional Chinese medicine formulas were included,involving 174 traditional Chinese medicines,of which 27 were used with a frequency of more than 3.The commonly used types are mainly heat-clearing medicines,deficiency tonifying medicine,diuresis and dampness medicines.Cluster analysis unveils 3 core formula groups,mainly focused on tonifying the spleen and eliminating dampness,as well as clearing heat and promoting blood circulation.According to the analysis of association rules,there are 4 drug pairs,16 three-herb groups and 4 four-herb groups,among which rhizoma atractylodis and phellodendron phello-dendri have the highest degree of support and serve as the core herb pair for reducing uric acid.Conclusion:The use of traditional Chinese medicine for lowering uric acid primarily focuses on clearing heat,promoting diuresis,activating blood circulation and resolving stasis.It is supplemented by drugs for invigorating the spleen,dispelling dampness,tonifying middle-Jiao and enhancing qi.This reflects the traditional Chinese medicine treatment principle of“treating both symptoms and root causes”,providing a reference for clinical application and development of new drugs.