摘要
目的:挖掘并分析白芥子临床外用规律。方法:检索近10年国家知识基础设施数据库(CNKI)中关于白芥子外用的临床研究文献,应用Excel 2021软件将得到的外用方剂的中药功效、性味归经、剂型用法以及各组方的主治疾病进行统计,运用Clementine12和IBM SPSS Statistics 25软件进行关联规则分析、因子分析和聚类分析,以此挖掘白芥子外用配伍规律。结果:1)在统计的107篇文献里得到中药组方111首,共含有中药187种。2)白芥子配伍中药大多为温里药、活血化瘀药和解表药,如细辛、附子、延胡索、麻黄等。3)性味主要以辛温为主,归经上多集中于肺经、心经和脾经。4)白芥子临床外用治疗疾病多为哮喘、关节炎、肺炎、鼻炎、癌痛等(多以儿童呼吸系统疾病为主)。5)白芥子外用常采用多种方剂剂型与给药方式,其中以饼剂或糊剂的穴位贴敷法为主。6)关联规则分析中得到高关联药物组合12个,公因子8个。系统聚类分析得到白芥子临床外用配伍共5类。结论:白芥子临床外用多治疗呼吸系统疾病及炎性疾病且外用时多与细辛、附子、延胡索等中药联用。希望借助数据挖掘的方法来探究白芥子的外用特点,为今后的临床应用和相关实验研究提供一定参考。
Objective:To excavate and analyze the rule of clinical external use of white mustard seeds.Methods:The clinical research literature on the topical use of white mustard seeds in the China National Knowledge Infrastructure(CNKI)database in the past ten years was retrieved,and Excel 2021 software was used toanalyze the efficacy,properties,taste,meridian tropism,dosage form and main indications of each topical formula,.Clementine12 and IBM SPSS Statistics 25 software were used for association rule analysis,factor analysis and cluster analysis,in order to find out the compatibility rule of white mustard seeds for external use.Results:1)A total of 111 prescriptions of traditional Chinese medicine(TCM)were obtained from 107 articles,containing 187 kinds of TCM.2)Most of the TCM compatible with white mustard seeds are warming interior formula,blood-activating and stasis-resolving medicinal and exterior-releasing formula,such as asarum,aconite,corydalis,ephedra and so on.3)The drugs are mainly pungent in flavor and warm in nature,and most of them are concentrated in the lung meridian,heart meridian and spleen meridian.4)White mustard seeds are commonly used for external treatment of diseases such as asthma,arthritis,pneumonia,rhinitis,cancer pain,etc.(mainly respiratory diseases in children).5)White mustard seeds are often externally used in a variety of dosage forms and administration methods,with the main method being acupoint sticking therapy with medicinal cake or paste.6)In the analysis of association rules,12 highly-relevant drug combinations and 8 common factors were obtained.Systematic cluster analysis showed that there were 5 types of compatibility of white mustard seeds for clinical external use.Conclusion:White mustard seeds are commonly externally used for the treatment of respiratory diseases and inflammatory diseases,and are often used in combination with TCM such as asarum,aconite and corydalis.It is hoped to use data mining methods to explore the characteristics for the external use of white mustard seeds,which will provide certain references for future clinical applications and related experimental studies.
作者
陈科旭
李秀敏
苗明三
CHEN Kexu;LI Xuimin;MIAO Mingsan(Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《世界中医药》
CAS
北大核心
2024年第1期100-104,共5页
World Chinese Medicine
基金
国家中医药管理局标准化项目(GZY-FJS-2020-219)
河南省重大公益专项(201300310100)
河南省药品监督管理局科技计划项目(2020DB050-55)。
关键词
白芥子
外用
数据挖掘
关联规则
因子分析
聚类分析
White mustard seeds
External use
Data mining
Association rules
Factor analysis
Cluster analysis