特发性全面性癫痫动态功能连接的应用及进展

The application and progress of dynamic functional connectivity in idiopathic generalized epilepsy

特发性全面性癫痫(idiopathic generalized epilepsy,IGE)是一组和遗传因素密切相关的癫痫综合征,主要临床表现为癫痫的全面性发作,在脑电图(electroencephalogram,EEG)上表现为全面性或双侧对称性异常放电,而常规MRI检查为阴性。随着MRI新方法的逐步运用,如今在IGE发生发展机制研究上取得了一定进展,但尚未完全阐明。近年来,动态功能连接(dynamic functional connectivity,DFC)作为一种新的脑网络分析方法,逐渐被应用到神经科学研究中,用于分析认知功能障碍与动态信息传递及整合方面的关联性,为人们进一步了解IGE的发生发展机制提供了有价值的新见解。在此,本文对近些年来有关IGE的DFC研究应用及进展进行综述,希望为IGE的研究提供一定的参考。

Idiopathic generalized epilepsy(IGE)is a group of generalized epilepsy syndromes closely related to genetic factors,with the main clinical manifestation of generalized seizures,which are manifested as generalized or bilateral symmetrical abnormal discharges on electroencephalogram(EEG),and routine MRI is negative.With the use of new methods of MRI,some progress has been made in the study of the mechanism of IGE occurrence and development,but it is still not fully elucidated.In recent years,dynamic functional connectivity(DFC),as a new network analysis method,has been gradually applied to the neuroscientific study of IGE to analyze the association between cognitive dysfunction and dynamic information transfer and integration,which provides valuable new insights into the developmental mechanism of IGE.Insights.In this paper,we summarize the application and progress of DFC research on IGE in recent years,hoping to provide certain reference for IGE research.