贝母瓜蒌散加减联合GP方案治疗阴虚热毒型肺腺癌临床观察

Efficacy observation of modified Beimu Gualou powder and GP regimen on lung adenocarcinoma with syndrome of yin deficiency and toxic heat

目的:观察贝母瓜蒌散加减联合GP方案治疗阴虚热毒型肺腺癌的临床疗效。方法:将符合阴虚热毒型肺腺癌诊断标准的52例患者,随机分为两组各26例,治疗组予贝母瓜蒌散加减联合GP方案化疗,对照组单予GP方案化疗,28天为1个周期,连用2个周期后观察两组患者近期客观疗效、临床症状体征积分变化、卡氏评分变化。结果:治疗组总控制率为69.23%,对照组为53.85%;两组比较差异无统计学意义(P>0.05)。治疗后,两组患者的症状体征积分明显降低,卡氏评分上升,与治疗前比较,差异均有统计学意义(P<0.05);与对照组比较,治疗组症状体征积分及卡氏评分改善更明显,差异均有统计学意义(P<0.05)。结论:贝母瓜蒌散加减联合GP方案治疗阴虚热毒型肺腺癌患者疗效较好,可改善症状体征,提高患者生存质量。

Objective:To observe the clinical efficacy of modified Beimu Gualou powder and GP regimen on lung adenocarcinoma with syndrome of yin deficiency and toxic heat.Methods:52 cases of patients who met the diagnostic criteria for lung adenocarcinoma with syndrome of yin deficiency and toxic heat were randomly divided into two groups,26 cases in each group.The treatment group was treated with modified Beimu Gualou powder and GP regimen for chemotherapy,while the control group was treated only with GP regimen for chemotherapy.28 days as a cycle.After two continuous cycles,short-term objective efficacy,changes of clinical symptoms,physical signs score and Karnofsky score of patients were observed in two groups.Results:The total control rate was 69.23%in the treatment group and 53.85%in the control group,and the comparative difference between two groups was not statistically significant(P﹥0.05).After treatment,the scores of symptoms and physical signs of patients in two groups were decreased significantly,while Karnofsky score was increased,and the differences were statistically significant compared with that before treatment(P<0.05).Compared with control group,the scores of symptoms and physical signs of treatment group were decreased more obviously,Karnofsky score was improved more obviously,and the differences were statistically significant(P<0.05).Conclusion:The clinical efficacy of modified Beimu Gualou powder and GP regimen on lung adenocarcinoma with syndrome of yin deficiency and toxic heat is better,which can improve symptoms and physical signs and enhance the quality of life of patients.