针刺配合中药治疗气血亏虚型肺癌癌因性疲乏的疗效观察

Observations on the efficacy of acupuncture plus Chinese herbal medicine for cancer-related fatigue in lung cancer of qi and blood deficiency type

目的 观察针刺配合和胃养血方治疗气血亏虚型肺癌癌因性疲乏的临床疗效。方法 将59例气血亏虚型肺癌癌因性疲乏患者随机分为治疗组(29例)和对照组(30例)。治疗组采用针刺配合和胃养血方治疗,对照组采用假针刺配合和胃养血方治疗。观察两组治疗前后Piper疲乏修订量表(revised Piper fatigue scale,PFS-R)及欧洲癌症研究与治疗组织生存质量核心量表(European Organisation for Research and Treatment of Cancer core quality of life questionnaire, EORTC QLQ-C30)各项评分的变化情况,并比较两组临床疗效。结果 两组治疗后PFS-R各项评分均较同组治疗前显著降低(P<0.05)。治疗组治疗前后PFS-R各项评分差值与对照组比较,差异均具有统计学意义(P<0.05,P<0.01)。治疗组治疗后EORTC QLQ-C30中躯体功能、角色功能、认知功能及疲倦评分均较同组治疗前显著降低(P<0.05)。治疗组治疗后EORTC QLQ-C30中角色功能及疲倦评分均明显低于对照组,差异均具有统计学意义(P<0.05)。治疗组治疗后总有效率为31.0%,对照组为17.2%,两组比较差异无统计学意义(P>0.05)。结论 针刺配合和胃养血方能改善肺癌患者疲乏状态及生活质量。

Objective To observe the clinical efficacy of acupuncture plus He Wei Yang Xue prescription for cancer-related fatigue in lung cancer of qi and blood deficiency type.Method Fifty-nine patients with lung cancer of qi and blood deficiency type were randomized to a treatment group(29 cases)and a control group(30 cases).The treatment group received acupuncture plus He Wei Yang Xue prescription and the control group,sham acupuncture plus He Wei Yang Xue prescription.The revised Piper fatigue scale(PFS-R)item scores and the European Organisation for Research and Treatment of Cancer quality of life questionnaire core 30(EORTC QLQ-C30)item scores were recorded in the two groups before and after treatment.The clinical therapeutic effects were compared between the two groups.Result The PFS-R item scores decreased significantly in the two groups after treatment compared with before(P<0.05).There were statistically significant differences in pre-/post-treatment difference values of the PFS-R item scores between the treatment and control groups(P<0.05,P<0.01).The EORTC QLQ-C30 physical,role and cognitive function scores and fatigue score decreased significantly in the treatment group after treatment compared with before(P<0.05).After treatment,the EORTC QLQ-C30 role function and fatigue scores were significantly lower in the treatment group than in the control group with statistically significant differences(P<0.05).The total efficacy rate was 31.0%in the treatment group and 17.2%in the control group with no statistical significant difference between the two groups(P>0.05).Conclusion Acupuncture plus He Wei Yang Xue prescription can reduce the state of fatigue and improve the quality of life in patients with lung cancer.