环状RNA在新生儿缺氧缺血性脑病中的作用研究进展

Research progress on the role of circular RNA in neonatal hypoxicischemic encephalopathy

新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)是新生儿死亡及儿童伤残的主要原因之一。尽管亚低温治疗已成为常规手段,但目前治疗HIE的方法有限且效果不理想。此外,由于时间和设备的限制,亚低温治疗无法及时应用,治疗后仍存在较高的死亡率或不同程度的神经功能障碍。因此,探索HIE的其他有效治疗方法成为新生儿领域研究的热点和难点。研究证明HIE可引起神经系统在生理、细胞和分子水平上复杂变化,环状RNA(circRNA)在中枢神经系统中高度表达,并参与调节生理和病理生理过程,因此有望成为HIE的潜在治疗靶点。本文综述HIE中circRNA对不同神经细胞的调控作用,旨在为治疗HIE提供新的理论依据。

Hypoxic-ischemic encephalopathy(HIE)is a major cause of newborn mortality and childhood disability.Despite hypothermia treatment being the current standard method,it has its limitations and often produces unsatisfactory outcomes.Additionally,due to time and equipment constraints,hypothermia treatment cannot be promptly administered,leading to high mortality rates or varying levels of neurological impairments even after treatment.Hence,the exploration of alternative and effective treatment methods for HIE has become a challenging and highly researched topic in the field of neonatology.Research has shown that HIE induces intricate changes in the neurological system at the physiological,cellular,and molecular levels.Circular RNA(circRNA)exhibits high expression in the central nervous system and plays a role in regulating physiological and pathophysiological processes.Therefore,circRNA holds promise as a potential therapeutic target for HIE.This article provides a comprehensive overview of the regulatory effects of circRNA on different types of neural cells in HIE,aiming to offer new theoretical foundations for the treatment of HIE.