鼻窦炎口服液对慢性鼻-鼻窦炎患者的作用效果

Effect of Sinusian Oral Liquid on Patients with Chronic Rhinosinusitis

目的分析鼻窦炎口服液对慢性鼻-鼻窦炎患者的作用效果。方法选取许昌市中心医院2019年3月至2021年9月收治的402例慢性鼻-鼻窦炎患者,随机分为布地奈德组(201例)和口服液组(201例)。布地奈德组接受布地奈德吸入气雾剂治疗,口服液组在布地奈德组的基础上接受鼻窦炎口服液治疗,两组均治疗2周,后随访1 a。统计两组治疗2周后的临床疗效及随访期间复发情况,比较两组治疗前及治疗2周后临床症状、免疫功能、嗅觉功能、鼻黏液纤毛传输速度、生活质量、内镜检查情况。结果治疗2周后,口服液组总有效率为93.53%,高于布地奈德组的86.57%(P<0.05);随访期间,口服液组复发率(2.49%)低于布地奈德组(9.45%)(P<0.05)。治疗2周后与治疗前比较,两组鼻漏、鼻塞、流涕、喷嚏、嗅觉下降、面颊部疼痛及Lund-Kennedy评分、外周血CD8^(+)水平降低,且口服液组低于布地奈德组(P<0.05)。治疗2周后与治疗前比较,两组外周血CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)及鼻黏膜纤毛输送率、鼻黏膜纤毛清除率、健康状况调查简表评分升高,口服液组高于布地奈德组(P<0.05)。治疗2周后与治疗前比较,两组嗅觉功能Ⅰ级患者占比均升高,口服液组高于布地奈德组(P<0.05);嗅觉功能Ⅲ级患者占比均降低,口服液组低于布地奈德组(P<0.05)。结论鼻窦炎口服液治疗慢性鼻-鼻窦炎患者,可有效缓解患者临床症状,改善其免疫功能、嗅觉功能、鼻黏液纤毛传输速度、内镜检查情况,提高其生活质量,预防疾病复发,具有较好的治疗效果。

Objective To analyze the effect of sinusian oral liquid on patients with chronic rhinosinusitis.Methods A total of 402 patients with chronic rhinosinusitis admitted to Xuchang Central Hospital from March 2019 to September 2021 were divided into the budesonide group(201 cases)and the oral liquid group(201 cases)by random number table method.The budesonide group was treated with budesonide inhalation aerosol,and the oral liquid group was treated with sinusitis oral liquid on the basis of the budesonide group.Both groups were treated for 2 weeks and followed up for 1 year.The clinical efficacy after 2 weeks of treatment and recurrence during the follow-up period of the 2 groups were counted,and the clinical symptoms,immune function,olfactory function,nasal mucociliary transmission speed,quality of life and endoscopic examination were compared before and after 2 weeks of treatment of the 2 groups.Results After 2 weeks of treatment,the total effective rate in the oral liquid group was 93.53%,which was higher than that in the budesonide group(86.57%)(P<0.05).During the follow-up period,the recurrence rate of the oral liquid group(2.49%)was lower than that of the budesonide group(9.45%)(P<0.05).After 2 weeks of treatment,compared with before treatment,the scores of nasal leakage,nasal congestion,runny nose,sneezing,decreased sense of smell,cheek pain,Lund-Kennedy and level of CD8^(+)in peripheral blood in the 2 groups decreased,and the oral liquid group were lower than those in the budesonide group(P<0.05).After 2 weeks of treatment,compared with before treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in peripheral blood,nasal mucociliary transport rate,nasal mucociliary clearance rate and score of 36-item short form survey in the 2 groups increased,and the oral liquid group were higher than those in the budesonide group(P<0.05).After 2 weeks of treatment,compared with before treatment,the proportion of patients with olfactory functionⅠin both groups increased,and the oral liquid group was higher than that in the budesonide group(P<0.05).The proportion of patients with gradeⅢolfactory function decreased,and the oral liquid group was lower than the budesonide group(P<0.05).Conclusion Treating patients with chronic rhinosinusitis with nasosinusitis oral liquid could effectively relieve their clinical symptoms,improve their immune function,olfactory function,nasal mucociliary transmission speed and endoscopic examination,improve their quality of life,and prevent the recurrence of the disease,which had a good therapeutic effect.