益气化湿解毒汤辅助重组人干扰素α2b凝胶治疗慢性宫颈炎及对NKTs、IL-4的影响

Effect of Yiqi Huashi Jiedu Decoction(益气化湿解毒汤)on NKTs and IL-4 in Patients with Chronic Cervicitis treated with Recombinant Human Interferonα2b Gel

目的 研究益气化湿解毒汤辅助重组人干扰素α2b凝胶治疗慢性宫颈炎的疗效及对患者自然杀伤T细胞(Natural killer T cells, NKTs)、白细胞介素-4(Interleukin-4,IL-4)的影响。方法 将2020年1月—2022年1月104例在医院确诊为慢性宫颈炎患者采用简单随机分为常规组(52例)和方剂组(52例)。常规组给予重组人干扰素α2b凝胶治疗,方剂组则在常规组基础上给予益气化湿解毒汤治疗,分析两组用药后的临床效果。结果 方剂组总有效率为90.38%(47/52),高于常规组的75.00%(39/52)差异有统计学意义(P<0.05);不良反应率为9.62%(5/52)与常规组的7.69%(4/52)比较,差异无统计学意义(P>0.05);停药后3个月复发率为9.62%(5/52),低于常规组的23.08%(13/52),差异有统计学意义(P<0.05)。方剂组阴道排液时间(7.28±2.96)d、宫颈修复时间(26.79±4.47)d短于常规组(14.02±4.56)d、(37.88±6.14)d,有统计学意义(P<0.05)。两组治疗前细胞因子组间比较,差异无统计学意义(P>0.05)。方剂组治疗后NKTs高于常规组,IL-4、超氧化物歧化酶(Superoxide dismutase, SOD)、前列腺E2(Prostate E2,PGE2)低于常规组(P<0.05)。结论 益气化湿解毒汤辅助重组人干扰素α2b凝胶治疗慢性宫颈炎可促进宫颈修复和阴道排液,调节NKTs、IL-4、SOD、PGE2的表达水平,安全性高,复发率低。

Objective To study the effect of Yiqi Huashi Jiedu Decoction(益气化湿解毒汤)combined with recombinant human interferonα2b gel on natural killer T cell(NKTs)and interleukin-4(IL-4)in patients with chronic cervicitis.Methods A total of 104 patients with chronic cervicitis diagnosed in the hospital from January 2020 to January 2022 were randomly divided into routine group(52 cases)and prescription group(52 cases).The routine group was treated with recombinant human interferonα2b gel,and the prescription group was treated with Yiqi Huashi Jiedu Decoction on the basis of the routine group.The clinical effects of the two groups were analyzed.Results The total effective rate in the prescription group was 90.38%(47/52),which was higher than 75.00%(39/52)in the routine group.The adverse reaction rate was 9.62%(5/52)in the prescription group and that was 7.69%(4/52)in the routine group,without statistical significance(P>0.05).The recurrence rate 3 months after drug withdrawal was 9.62%(5/52)in the prescription group,which was lower than 23.08%(13/52)in the routine group,with statistical significance(P<0.05).The vaginal discharge time[(7.28±2.96)d]and the cervical repair time[(26.79±4.47)d]in the prescription group were shorter than those in the routine group[(14.02±4.56)d and(37.88±6.14)d],with statistical significance(P<0.05).There was no statistical significance in the comparison of cytokines between the two groups before treatment(P>0.05).After treatment,NKTs in the prescription group were higher than those in the routine group,and the levels of IL-4,superoxide dismutase(SOD)and prostate E2(PGE2)were lower than those in the routine group(P<0.05).Conclusion Yiqi Huashi Jiedu Decoction combined with recombinant human interferonα2b gel in the treatment of chronic cervicitis can promote cervical repair and vaginal drainage,regulate the levels of NKTs,IL-4,SOD and PGE2,with high safety and low recurrence rate.