CIRBP/TLR4/MyD88/NF-κB信号通路在妊娠期糖尿病中的研究进展

Research Progress of CIRBP/TLR4/MyD88/NF-κB Signaling Pathway in Gestational Diabetes Mellitus

妊娠期糖尿病(GDM)患病人数呈逐年上升趋势,增加不良妊娠结局的发生率,对孕妇及其后代的健康产生不良影响,给社会造成较大的负担。但GDM发病机制尚未完全阐明,现有研究认为胰岛素抵抗是其发病的基础,机体炎症反应被认为与胰岛素抵抗发生发展密切相关。CIRBP/TLR4/MyD88/NF-κB信号通路是目前已知的重要炎症通路,其通过影响机体炎症因子释放诱导机体炎症反应发生,进而使机体发生胰岛素抵抗。故本文对CIRBP/TLR4/MyD88/NF-κB信号通路在妊娠期糖尿病的作用相关研究进行综述,以期为临床防治GDM提供新视角和新靶点。

The number of patients with gestational diabetes mellitus(GDM)is increasing year by year,which not only increases the incidence of adverse pregnancy outcomes,but also has a negative impact on the health of pregnant women and their offspring,causing a greater burden on society.However,the pathogenesis of GDM has not been fully elucidated.Existing studies suggest that insulin resistance is the basis of its pathogenesis,and the body's inflammatory response is considered to be closely related to the occurrence and development of insulin resistance.The CIRBP/TLR4/MyD88/NF-κB signaling pathway is currently known as an important inflammatory pathway,which induces the body's inflammatory response by affecting the release of inflammatory factors,thereby causing insulin resistance.Therefore,this article reviews the research on the role of CIRBP/TLR4/MyD88/NF-κB signaling pathway in gestational diabetes mellitus,in order to provide new perspectives and new targets for clinical prevention and treatment of GDM.