摘要
目的中药质量标志物(quality marker,Q-Marker)的确定是完善《中国药典》、促进中医药产业健康发展的关键内容,是中医药走向国际化和现代化需要迈出的重要一步,对Q-Marker的研究现状进行充分认识很有必要。方法采用科学计量分析方法,通过CNKI和Web of Science数据库检索中药Q-Marker相关文献,从论文的整体产出概况、研究国家和机构、研究热点及研究趋势等方面,借助VOSviewer、CiteSpace软件绘制可视化知识图谱。结果共纳入1030篇中、英文文献,分析可知中药Q-Marker研究正处于快速发展阶段,概念提出人刘昌孝院士的发文量最多,该研究领域在中药质量控制、药效物质基础、炮制机制研究、中药药理与安全性评价、中药资源种植等方向已取得大量研究成果。结论中药Q-Marker正处于研究的上升阶段,研究领域内各机构和团队之间的交流合作有待加强。通过全面、科学地总结中药Q-Marker研究领域的发展进程、研究近况,并探讨其研究热点趋势,可为中药Q-Marker的深入研究提供参考依据。
Objective The determination of quality marker(Q-Marker)in traditional Chinese medicine(TCM)is a crucial content in improving the Chinese Pharmacopoeia and promoting the healthy development of the TCM industry.It is an important step for TCM to internationalize and modernize.It is necessary to have a comprehensive understanding of the current research status of Q-Marker.Methods Using the scientometrical analysis method,the related literature of Q-Marker in TCM was retrieved through CNKI and Web of Science database.Visualization knowledge maps were generated using VOSviewer and CiteSpace to present the overall production of papers,research countries and institutions,research hotspots,and research trends.Results A total of 1030 Chinese and English literatures were included in the analysis.The analysis shows that the research on Q-Marker of TCM is in the stage of rapid development.Academician Liu Changxiao,the proposer of the concept,published the most papers.Research on Q-Marker in TCM has achieved abundant results in areas such as quality control of TCM,pharmacodynamic substances,processing mechanism research,pharmacology and safety evaluation of TCM,and cultivation of TCM resources.Conclusion The study of Q-Marker in TCM is currently in an upward stage,and there is a need to strengthen communication and cooperation among different institutions and research teams in this field.By comprehensively and scientifically reflecting the development process,current research status,and research hotspots and trends in the field of Q-Marker in TCM,this study provides a reference for the in-depth research on Q-Marker in TCM.
作者
徐园园
王明慧
魏永利
李峰
辛义周
XU Yuanyuan;WANG Minghui;WEI Yongli;LI Feng;XIN Yizhou(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Department of Pharmacy,Liaocheng People’s Hospital,Liaocheng 252000,China;Level Three Laboratory of Traditional Chinese Medicine Preparation of State Administration of Traditional Chinese Medicine,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China;Laboratory for Molecular Identification and Biological Evaluation of Chinese Herbal Pieces,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China)
出处
《中草药》
CAS
CSCD
北大核心
2024年第4期1297-1308,共12页
Chinese Traditional and Herbal Drugs
基金
国家中医药管理局公益性行业专项“中药炮制技术传承基地建设项目”(国中医药科技中药便函[2022]59号)
2022年全国名老中医药专家传承工作室建设项目:李峰全国名老中医药专家传承工作室(国中医药人教函[2022]75号)
第七批全国老中医药专家学术经验继承工作项目:第七批全国老中医药专家学术经验继承工作继承人(国中医药人教函[2022]76号)
山东省中医药科技重点项目(Z-2023052)
山东省中医药科技面上项目(M-2023166)
山东省齐鲁卫生与健康领军人才项目(2019)。