铁皮石斛保肝活性成分与作用机制研究进展

Research progress on liver-protective active components and mechanism of action of Dendrobii Officinalis Caulis

铁皮石斛Dendrobii Officinalis Caulis是我国传统的名贵中药,具有益胃生津、滋阴清热等功效,其活性成分能够缓解、治疗及调节多种疾病,具有很高的开发价值。铁皮石斛主要活性成分包括多糖、生物碱、黄酮类化合物、酚类和氨基酸类等,目前铁皮石斛的相关研究已明确了其活性化合物的结构及传统记载功效。通过对铁皮石斛中不同活性成分种类对肝脏的保护与作用机制进行总结,初步分析了铁皮石斛多糖和其他活性成分保肝功能的构效关系。为铁皮石斛在植物医学和现代药物的应用提供依据,为铁皮石斛的进一步开发利用提供参考。

Tiepishihu(Dendrobii Officinalis Caulis)is a precious traditional Chinese medicine in China,which has the effects of benefiting stomach,promoting fluid production,nourishing yin and clearing heat.The active ingredients of Dendrobii Officinalis Caulis could alleviate,treat and regulate various diseases,which have high development value.The main active components of Dendrobii Officinalis Caulis include polysaccharides,alkaloids,flavonoids,phenols and amino acids.Current studies on Dendrobii Officinalis Caulis have clarified the structure of its active compounds as well as pharmacological activities,in addition to the development of specific chemical components and traditionally documented efficacy.By summarizing the hepatoprotection and mechanism of action of different active ingredient species in Dendrobii Officinalis Caulis,the structure-activity relationship between the hepatoprotective functions of Dendrobii Officinalis Caulis polysaccharides and other active ingredients was preliminarily analyzed.It provides a basis for the application of Dendrobii Officinalis Caulis in phytomedicine and modern medicine,and provides a reference for the further development and utilization of Dendrobii Officinalis Caulis.