机械牵张力对创面愈合瘢痕形成不同时期影响机制研究进展

Research progress on the mechanism of mechanical tension affecting wound heeling in different periods

创面愈合瘢痕形成对患者的正常生活及心理健康造成影响,是整形外科中的棘手问题。近年来机械力及其信号传导对创口愈合的影响机制受到广泛关注,并为防治病理性瘢痕的相关研究提供了新思路。该文综述了机械牵张力对不同时期创面愈合影响机制的研究进展,在伤口愈合的止血炎症期、增殖期和组织重塑期3个阶段中,机械牵张力通过复杂的信号传导与反馈机制引起慢性炎症、纤维化增生、血管形成、细胞外基质重塑等生物学反应,对伤口愈合和瘢痕形成造成影响。该文还综述了近年临床与实验室关于创面愈合瘢痕形成的机械牵张力治疗研究的进展。

The formation of pathological scar has an impact on patients’normal life and mental health,which is also a thorny problem in plastic surgery.In recent years,the influence mechanism of mechanical tension and signal transduction on wound healing has attracted extensive attention and provides a new idea for the prevention and treatment of pathological scar.This paper reviews the research progress of the influence mechanism of mechanical stretch on wound healing in different stages.In the inflammatory stage,hyperplasia stage and tissue remodeling stage of wound healing,mechanical stretch tension causes biological reactions such as chronic inflammation,fibrosis,angiogenesis,and extracellular matrix remodeling through complex signal transduction and feedback mechanisms,which has an impact on wound healing and scar formation.Mechanical stretch therapy for wound healing and scar formation has also achieved certain result in clinical and basic study.