肠道微生物与子宫内膜癌相关危险因素的研究进展

Gut microbiota and risk factors of endometrial carcinoma:research progress

子宫内膜癌(endometrial carcinoma,EC)是一种常见的妇科恶性肿瘤,以雌激素升高、肥胖和胰岛素抵抗等临床表现为主要特征,这些特征影响了EC的进展及预后。肠道菌群是由大量微生物组成的复杂系统,它们维持着人体各系统的稳态并产生一些代谢产物来对机体发挥作用。但因其数量巨大,在菌群失调时可导致宿主生理机能发生紊乱,微生物产生的毒性代谢物参与炎症并增加与肿瘤相关的通路,影响机体的吸收代谢、肿瘤进展和恶化等。随着基因检测技术的发展,越来越多的证据表明肠道微生物与EC的危险因素存在相关性,能促进EC的发生发展。本文主要介绍肠道微生物对EC发生发展的影响,重点探讨肠道微生物与EC相关危险因素间的关系,以期为EC的治疗与预后管理提供新思路。

Endometrial carcinoma(EC)is a common gynecological malignant tumor characterized by elevated level of estrogen,obesity,insulin resistance and other clinical manifestations,which affect the progression and prognosis of EC.The gut microbiota is a complex system of a large number of microorganisms that maintain the homeostasis of the body's various systems and produce some metabolites to influence the body.However,because of the large number of microbiota,it does harms to the host when dysbiosis occurs,leading to disturbance of host physiology,while the toxic metabolites can cause inflammation,increase the pathways related to tumors,affect body absorption and metabolism,tumor progression and deterioration,etc.With the advancement of genetic testing technology,increasing evidences showed that there is a correlation between gut microbiome and the risk factors for EC,which promotes the occurrence and development of EC.In this review,we mainly introduce the influence of intestinal microorganisms on the development of EC,focus on the relationship between intestinal microorganisms and EC-related risk factors,and provide new ideas for EC treatment and prognosis management.