基于不同组织和器官角度回顾PGC-1α在运动抗衰老中的作用

Review of PGC-1αrole in exercise anti-aging in different tissues and organs

背景:过氧化物酶体增殖物激活受体γ共激活因子1α(peroxisome proliferators-activated receptors gamma co-activator 1α,PGC-1α)和衰老密切相关,且其在运动抗衰老中发挥着重要的调控作用,但缺乏从不同组织和器官视角下PGC-1α在运动抗衰老中作用的相关综述。目的:详细回顾PGC-1α在运动抗衰老中的作用,并从不同组织和器官的角度探讨其调控情况。方法:于2023-05-01/07-01进行文献检索。检索范围包括自各数据库建库至2023年7月,并在Web of Science、PubMed、中国知网、万方和维普数据库上进行检索。中文检索词:“PGC-1α,过氧化物酶体增殖物激活受体γ共激活因子1α,PPARGC1A,衰老,运动,老年人等”;英文检索词:“PGC-1α,aging,exercise,exercise training,older adults”。运用布尔逻辑运算符将检索词连接进行检索,并制定了相应的检索策略。根据纳入和排除标准进行筛选,最终纳入文献83篇进行综述分析。结果与结论:①PGC-1α是一个重要的转录共激活因子,在维持线粒体功能、调控能量代谢和适应不同代谢需求方面发挥着关键的调节作用。②在线粒体衰老中的多种功能,在多种细胞类型中的调节作用,在多种细胞类型中发挥着重要的调节作用,与炎症途径和氧化还原控制的关系及其相关蛋白修饰和表观遗传变化。③PGC-1α的表达水平能够被运动训练提高,并通过调节线粒体生物发生、能量代谢和抗氧化应激等途径发挥积极的作用,其在运动改善脂肪组织衰老、心血管老化、神经系统老化、肾脏衰老、骨骼肌衰老和肝脏老化等中发挥重要作用。④课题组专家建议未来研究方向包括探索不同类型、强度和时长的运动对PGC-1α表达的调节影响,研究PGC-1α的蛋白修饰和表观遗传变化的调节机制,以及加强对PGC-1α在不同衰老相关疾病中的作用机制的研究。

BACKGROUND:Peroxisome proliferators-activated receptor gamma co-activator 1α(PGC-1α)is closely related to aging and plays an important regulatory role in exercise anti-aging.However,there is a lack of comprehensive reviews on the role of PGC-1αin exercise anti-aging from the perspective of different tissues and organs.OBJECTIVE:To provide a detailed overview of the role of PGC-1αin exercise anti-aging and discuss its regulation from the perspective of different tissues and organs.METHODS:A literature search was conducted from May 1,2023 to July 1,2023.The search covered self-built databases up to July 2023,as well as databases such as Web of Science,PubMed,China National Knowledge Infrastructure(CNKI),WanFang,and VIP.The Chinese search terms included“PGC-1α,peroxisome proliferators-activated receptor gamma co-activator 1α,PPARGC1A,aging,exercise,older adults”.The English search terms were“PGC-1α,aging,exercise,exercise training,older adults”.Boolean logical operators were used to connect the search terms,and corresponding search strategies were developed.Based on inclusion and exclusion criteria,83 articles were included in the review.RESULTS AND CONCLUSION:(1)PGC-1αis an important transcriptional coactivator that plays a key regulatory role in maintaining mitochondrial function,regulating energy metabolism,and adapting to different metabolic demands.(2)PGC-1αhas a significant regulatory role in mitochondrial aging and various functions in multiple cell types,and is associated with inflammatory pathways,redox control,protein modifications,and epigenetic changes.(3)The expression level of PGC-1αcan be increased by exercise training,and it exerts positive effects through regulating mitochondrial biogenesis,energy metabolism,and anti-oxidative stress pathways.It plays an important role in exercise-induced improvement of adipose tissue aging,cardiovascular aging,neurosystem aging,renal aging,skeletal muscle aging,and liver aging.(4)The expert group recommends future research directions including exploring the regulatory effects of different types,intensities,and durations of exercise on PGC-1αexpression,studying the regulatory mechanisms of protein modifications and epigenetic changes in PGC-1α,and strengthening the research on the mechanisms of PGC-1αin different aging-related diseases.