摘要
转移是晚期胃癌患者的主要表现及治疗失败的主要原因。部分胃癌转移相关因子通过对上皮间充质转化、黏附、迁移、侵袭、增殖、血管生成等过程的调控促进或抑制胃癌转移。本文拟对胃癌转移相关因子对胃癌转移过程不同阶段的作用及潜在分子机制作一综述,明确其调控胃癌转移的机制及潜在的治疗靶点,为胃癌转移提供新的检测手段及治疗选择。
Metastasis is the main manifestation of advanced gastric cancer patients and the main cause of treatment failure.Some gastric cancer metastasis related factors promote or inhibit gastric cancer metastasis by regulating epithelial-mesenchymal transition,adhesion,migration,invasion,proliferation and angiogenesis.This article aims to provide a view of the effects and potential molecular mechanisms of gastric cancer metastasis related factors in different stages of gastric cancer metastasis,clarify their mechanisms of regulating gastric cancer metastasis and potential therapeutic targets,provide new detection methods for gastric cancer metastasis and new treatment options for patients with metastasis gastric cancer.
作者
魏秀珍
张政杰
谭勇
李加佳
张百红
Wei Xiuzhen;Zhang Zhengjie;Tan Yong;Li Jiajia;Zhang Baihong(The First Clinical Medical School,Gansu University of Chinese Medicine,Lanzhou 730030;Department of Oncology,the 940th Hospital ofJoint Logistics Support Force of People′s Liberation Army,Lanzhou 730050;Department of Gastroenterology,the Wu Wei Liang Zhou Hospital,Wuwei 733000;Department of Gastroenterology,the 940th Hospital of Joint Logistics Support Force of People′s Liberation Army,Lanzhou 730050;Endoscopy Center of Gastroenterology Department,the 940th Hospital of Joint Logistics Support Force of People′s LiberationArmy,Lanzhou 730050)
出处
《国际老年医学杂志》
2024年第2期234-237,共4页
International Journal of Geriatrics
基金
甘肃省自然科学基金(22JR5RA007)。
关键词
胃癌
肿瘤转移
转移相关因子
Stomach cancer
Neoplasm metastasis
Metastasis related factors
