感染性肺炎新生儿的血清25-羟基维生素D与炎症因子的相关性分析

Correlation between serum 25‐hydroxyvitamin D and inflammatory cytokines in neonatal pneumonia

目的分析感染性肺炎新生儿的血清25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]与炎症因子干扰素-γ(infectious pneumonia-γ,IFN-γ)、C-反应蛋白(C-reactive protein,CRP)、白细胞介素-2(interleukin-2,IL-2)水平的相关性。方法选取河北省秦皇岛市第一医院2018年12月至2020年12月收治的100例感染性肺炎新生儿,根据血清25(OH)D水平分为缺乏组(≤15.0μg/L,18例)、不足组(15.1~20.0μg/L,42例)、充足组(>20.0μg/L,40例)。统计3组性别、胎龄、血清25(OH)D水平、出生体重、分娩方式等一般资料和临床资料,比较3组IFN-γ、CRP及IL-2水平,分析新生儿血清25(OH)D水平与IFN-γ、CRP、IL-2水平的相关性。结果3组胎龄、性别、出生体质量、分娩方式比较差异无统计学意义(P>0.05);缺乏组、不足组、充足组新生儿的血清25(OH)D水平逐渐升高,差异有统计学意义(P<0.05)。缺乏组IFN-γ、CRP及IL-2水平均高于不足组、充足组(P<0.05),不足组IFN-γ、CRP及IL-2水平高于充足组(P<0.05)。经Pearson相关分析,感染性肺炎新生儿血清25(OH)D水平与IFN-γ、CRP、IL-2水平呈负相关(P<0.05)。结论新生儿血清25(OH)D越低,维生素D越缺乏,IFN-γ、CRP及IL-2水平越高,感染性肺炎的风险越高。

Objective To analyze the correlation between serum 25⁃hydroxyvitamin D[25(OH)D]and inflammatory cytokines such as interferonγ(IFN⁃γ),C⁃reactive protein(CRP)and interleukin⁃2(IL⁃2)in neonatal pneumonia.Methods A total of 100 neonates admitted to First Hospital of Qinhuangdao from December 2018 to December 2020 were enrolled in this study.According to the serum 25(OH)D level,they were divided into deficiency group(≤15.0μg/L,n=18),inadequate group(15.1⁃20μg/L,n=42),and adequate group(>20.0μg/L,n=40).The general and clinical data such as gender,gestational age,serum 25(OH)D level,birth weight,mode of delivery and the levels of IFN⁃γ,CRP and IL⁃2 were compared among the three groups.The correlation between vitamin D deficiency and levels of IFN⁃γ,CRP and IL⁃2 was analyzed.Results There were no significant differences in gestational age,sex,birth weight,or delivery mode among the three groups(P>0.05).Serum 25(OH)D levels in the three groups were as follows:deficiency group<inadequate group<adequate group,and there were significant differences in the serum 25(OH)D level between groups(P<0.05).The levels of IFN⁃γ,CRP and IL⁃2 in the deficiency group were higher than those in the inadequate group and adequate group(P<0.05),and the levels of IFN⁃γ,CRP and IL⁃2 in the inadequate group were higher than those in the adequate group(P<0.05).The Pearson correlation analysis showed that serum 25(OH)D level was negatively correlated with IFN⁃γ,CRP and IL⁃2 levels in newborns(P<0.05).Conclusion The lower the serum 25(OH)D in newborns,the more deficient the vitamin D and the higher the levels of IFN⁃γ,CRP and IL⁃2 are,indicating higher risk of pneumonia.