基于阴阳平衡理论重识巨噬细胞在创面愈合中的动态变化和分子机制

Restudy of the dynamic changes and molecular mechanism of macrophages in wound healing based on yin-yang balance theory

阴阳平衡是中医理论的一个重要概念,中医学认为阴阳平衡才是机体的最佳状态。巨噬细胞调节创面再生修复,在不同刺激下可分化成M1型巨噬细胞和M2型巨噬细胞。M1型与M2型巨噬细胞在创面愈合过程中的动态变化与阴阳平衡理论内涵相似。如果在创面愈合过程中,巨噬细胞平衡被扰乱,阴阳失衡,则会导致过度炎症或者病理性瘢痕。以阴阳平衡理论为指导,从巨噬细胞表型出发就近年来对创面愈合的作用机制展开综述,以期为临床治疗提供新思路。

Yin-yang balance,an important concept in Chinese medicine,is considered to be the best state of the body in Chinese medicine.Macrophages regulate wound regeneration and repair,and can differentiate into M1 and M2 macrophages under different stimuli respectively.The dynamic changes of M1 and M2 macrophages during wound healing are similar to the connotation of yin-yang balance theory.If the balance of macrophages is disturbed during wound healing,yin and yang are out of balance,leading to excessive inflammation or pathological scarring.Guided by yin-yang balance theory,this paper reviews the mechanism of wound healing in recent years from the perspective of macrophage phenotype,in order to provide new ideas for clinical treatment.