基于肠肝轴中医药调节肠道功能防治肝细胞癌作用机制的研究进展

Research progress on the mechanism of Traditional Chinese Medicine regulating intestinal function in the treatment of hepatocellular carcinoma based on the gut liver axis

原发性肝癌是全球发病率和病死率较高的恶性肿瘤之一,其中肝细胞癌占90%以上。肠道和肝脏通过门静脉、胆道和体循环的双向连接进行交流,肠肝轴成为肝细胞癌发病机制中的重要环节。肠道屏障功能障碍和肠道微生物失调是肝细胞癌发生的重要因素。中医药临床应用已有数千年的历史,基于肠肝轴理论,中医药防治肝细胞癌可有效阻断肠道-肝脏信号,对肝细胞癌的精准预防与治疗具有重要意义。本文在中医药脏腑理论和肠肝轴理论的基础上,总结中医药及其活性成分对肝细胞癌的调节及干预作用,希望为肝细胞癌的进一步临床防治提供新的策略和思路。

Primary liver carcinoma is one of the malignant tumors with high incidence rate and mortality in the world,of which hepatocellular carcinoma accounts for more than 90%.The intestine and liver communicate through bidirectional connections between the portal vein,bile duct,and systemic circulation,and the gut liver axis becomes an important link in the pathogenesis of hepatocellular carcinoma.Intestinal barrier dysfunction and dysbiosis of gut microbiota are important factors in the occurrence of hepatocellular carcinoma.Traditional Chinese Medicine has a history of thousands of years in clinical application.Based on the theory of the gut liver axis,Traditional Chinese Medicine can effectively block the gut liver signal in the prevention and treatment of hepatocellular carcinoma,which is of great significance for precise prevention and treatment of hepatocellular carcinoma.This article summarizes the regulatory and intervention effects of Traditional Chinese Medicine and its active ingredients on hepatocellular carcinoma based on the theory of visceral organs and the theory of gut liver axis,hoping to provide new strategies and ideas for further clinical prevention and treatment of hepatocellular carcinoma.