针刺治疗偏头痛的机制研究进展

Research progress of mechanism of acupuncture for migraine

检索中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普资讯中文期刊服务平台(VIP)、中文科技期刊全文数据库、PubMed、Medline、Cochrane Library数据库2013-2023年收录的关于针刺治疗偏头痛的机制研究的文献,从三叉神经血管系统机制、代谢相关机制、遗传学机制、大脑结构与功能改变方面梳理偏头痛的发病机制及针刺治疗偏头痛的可能机制。发现目前针刺治疗偏头痛的机制以三叉神经血管系统研究最多,已有研究证实针刺对皮层扩散性抑制(CSD)、星形胶质细胞和神经源性激肽等三叉神经系统相关环节有确切的调节作用;代谢相关机制及遗传因素虽然越来越被关注,但其在针刺治疗偏头痛机制方面的研究还较少,需要进一步深入探索;偏头痛的脑结构与功能的研究越来越深入,但研究存在一些争议,未来需要更大样本量和规范设计的研究方案,以进一步探索针刺治疗偏头痛的机制。

The literature regarding the action mechanism of acupuncture for migraine published from 2013 to 2023 was searched in China National Knowledge Infrastructure(CNKI),Wanfang,VIP,Chinese Science and Technology Periodical Database,PubMed,Medline,and Cochrane Library.The pathogenesis of migraine and potential mechanisms of acupuncture treatment were summarized from the aspects of trigeminovascular system(TGVS),metabolic-related mechanisms,genetic factors,and alterations in brain structure and function.The results revealed that current research on the mechanisms of acupuncture for migraine predominantly centered around the TGVS,with studies confirming the specific regulatory effects of acupuncture on trigeminal system-related components,such as cortical spreading depression(CSD),astrocytes,and neurogenic kinin.While metabolic-related mechanisms and genetic factors are gaining attention,further in-depth exploration is needed to fully understand their roles in the mechanism of acupuncture for migraine.The study of brain structure and function in migraine has advanced,albeit with some controversies.Future research should prioritize larger sample sizes and standardized study designs to delve deeper into the mechanisms of acupuncture in treating migraine.