子宫颈高危型人乳头瘤病毒感染的中西医治疗研究进展

Research Progress in the Treatment of High-risk Human Papillomavirus Infection of Cervix by Traditional Chinese Medicine and Western Medicine

宫颈癌是我国女性第6位高发恶性肿瘤,严重危害女性生命健康,而子宫颈高危型人乳头瘤病毒(HPV)的持续感染是诱发宫颈癌及宫颈上皮内瘤样病变(CIN)的主要因素。由于从病毒感染进展为宫颈癌需要较长时间,针对病因,及时阻断子宫颈高危型HPV感染,有效阻止病情进展,防止宫颈癌的发生尤为重要。西医外用药物、消融及手术治疗存在易复发、出血、感染及术后影响生育功能等并发症,中医辨证论治,在病情不同阶段均可提供有效干预,且中药多靶点,与多个信号通路发生作用,与西医协同治疗可优势互补,提高疗效。通过综述中西医治疗子宫颈高危型HPV的主要方法,为该病临床诊治提供思路,同时综述子宫颈高危型HPV感染实验模型及中医药抗高危型HPV感染作用机制,为进一步实验研究提供参考。

Cervical cancer gains the sixth high incidence of female malignant tumor in China,which seriously endangers women′s health.The continuous infection of high-risk human papillomavirus(HPV) in the cervix is the main factor inducing cervical cancer and cervical intraepithelial neoplasia(CIN).Since it takes a long time from high-risk HPV infection to cervical cancer,it is particularly important to block cervical high-risk HPV infection in time to effectively prevent the progress of the disease and avoid the occurrence of cervical cancer.Western medicine for external use,ablation,and surgical treatment can lead to complications such as relapse,bleeding,infection and postoperative impact on fertility..On the contrary,traditional Chinese medicine treatment based on syndrome differentiation can provide effective intervention in different stages of disease.Besides,Chinese medicine has multiple targets and interacts with multiple signaling pathways.So it′s a good idea to integrate traditional Chinese medicine and Western medicine to improve clinical efficacy for high-risk HPV infection of cervix.In this paper,the main methods of traditional Chinese medicine and Western medicine for high-risk HPV infection of cervix were reviewed,which provides ideas for the clinical diagnosis and treatment of the disease.Meanwhile,the experimental model of high-risk HPV infection of cervix and the mechanism of traditional Chinese medicine against high-risk HPV infection were reviewed,providing reference for further experimental research.