缺血性脑卒中免疫炎症机制及中医药干预研究进展

Advances in the Study of Immunoinflammatory Mechanisms and Treatment of Chinese Medicine in Ischemic Stroke

缺血性脑卒中由于脑血管局部缺血缺氧,继而激活血管内炎症反应,最终产生一系列中枢神经系统免疫应答反应,在脑损伤和神经修复过程中均发挥重要作用,与缺血性脑卒中的发生发展紧密相关。中性粒细胞、神经胶质细胞、淋巴细胞等免疫细胞具有双重作用,既能释放炎症介质加重脑损伤,又能释放神经营养物质和抗炎因子产生脑保护作用。通过整理缺血性脑卒中后血管内炎症反应及中枢神经系统免疫应答机制,以及中医药对相关免疫细胞的干预作用,以期为缺血性脑卒中的治疗提供证据和思路。

Ischemic stroke is closely related to the development of ischemic stroke due to local ischemia and hypoxia in the cerebral vasculature,followed by activation of intravascular inflammatory responses and ultimately a series of central nervous system immune responses,which play an important role in both brain injury and neurological repair processes.Neutrophils,glial cells,lymphocytes and other immune cells have a dual role,which can release pro-inflammatory factors to aggravate brain injury,as well as release neurotrophic and anti-inflammatory factors for brain protection.This article reviews the mechanisms of the intravascular inflammatory response and immune response of central nervous system after ischemic stroke and the role of Chinese Medicine on immune cells involved in this process,aiming to provide evidence and ideas for the treatment of ischemic stroke.