基于质谱的肿瘤标志物筛选研究进展

Progress in Tumor Biomarker Screening Based on Mass Spectrometry

随质谱技术的飞速发展,其在肿瘤标志物研究领域的应用日益扩大。该文从样品预处理、质谱检测和临床应用这三个方面详细介绍了质谱技术在核酸、蛋白质和代谢物层面筛选肿瘤标志物的最新研究进展,总结了不同质谱方法的优势与挑战。最后对基于质谱技术的肿瘤标志物筛选的未来发展方向进行了系统性展望,预期为相关领域研究提供可靠依据。

With the rapid development of mass spectrometry technology,its application in tumor biomarker research is expanding.This review details the latest research progress of mass spectrometry in tumor biomarker screening at the level of nucleic acids,proteins and metabolites from the three aspects of sample pretreatment,mass spectrometry detection,and clinical application,and then summarizes the advantages and challenges of different mass spectrometry methods.Finally,a systematic outlook on the prospects of mass spectrometry-based tumor biomarker screening is presented.It is expected to provide a valuable reference for the researches in related fields.