cGAS-STING信号通路在肿瘤发展及靶向治疗中的研究进展

Advances in the Research of cGAS-STING Signaling Pathway in Tumor Development and Targeted Therapy

cGAS-STING信号通路是识别细胞质中DNA、启动固有免疫应答的重要通路,可通过多种机制调控肿瘤的发生发展和抗肿瘤免疫反应。该文概述了cGAS-STING通路的分子特征及信号转导途径,探讨了其在不同条件下调控肿瘤发生发展的复杂机制及肿瘤中cGAS-STING通路的调控机制,介绍了靶向该通路的小分子激动剂及其与其他癌症疗法的联合应用,为靶向cGASSTING通路的新型肿瘤临床治疗方案的开发提供参考。

cGAS-STING signaling pathway is an important pathway for recognizing DNA in the cytoplasm and initiating immune response,which can regulate tumor development and anti-tumor immunity through various mechanisms.This article outlines the molecular characteristics and signal transduction of cGAS-STING pathway,discusses its complex mechanisms in regulating tumor development under different conditions and the regulatory factors of cGAS-STING pathway in tumors,and summarizes small-molecule agonists targeting this pathway and their combination medication with other cancer therapies to provide reference for the development of novel tumor clinical therapeutic programs targeting cGAS-STING pathway.