凉粉草中2个新的倍半萜苯甲酰酯

Two new benzoyl-sesquiterpenes from Mesona chinensis

凉粉草是岭南地区常用的药食两用植物,具有广泛的药理活性,但其化学成分研究尚不充分。该研究运用多种现代色谱分离技术,从凉粉草地上部位的95%乙醇提取物中分离得到了2个化合物,综合使用紫外光谱(UV)、红外光谱(IR)、高分辨质谱(HR-ESI-MS)、一维和二维核磁共振技术(1D NMR和2D NMR)、单晶X射线衍射技术(SC-XRD)等结构鉴定方法确定了它们的绝对构型,为2个新的倍半萜苯甲酰酯类化合物,并分别命名为凉粉草醇甲(mesonanol A)和凉粉草醇乙(mesonanol B)。药理活性评价结果显示,2个新化合物均未表现出明显的抗病毒和抗炎活性。

Mesona chinensis is a common medicinal and edible plant in the Lingnan region of China,which has extensive pharmacological activity.However,the study of its chemical constituents is not sufficient.In this study,a variety of modern chromatographic separation techniques were used to isolate two compounds from 95%ethanol extract of the grass parts of M.chinensis.Their absolute configurations were determined by ultraviolet spectroscopy(UV),infrared spectroscopy(IR),high resolution mass spectrometry(HR-ESI-MS),1D and 2D nuclear magnetic resonance(1D NMR and 2D NMR),and single-crystal X-ray diffraction(SC-XRD).Specifically,they were two new benzoyl-sesquiterpenes and named mesonanol A and mesonanol B,respectively.The results of the pharmacological activity evaluation showed that neither of the two new compounds showed obvious antiviral and antiinflammatory activities.