中成药临床证据知识图谱元素关系与延展路径

Element relationship and extension path of clinical evidence knowledge map with Chinese patent medicine

研究构建中成药临床证据知识图谱元素关系与延展路径,为中成药证据链形成与转化应用提供基础技术支持,为海量中成药临床杂乱小数据提供收集、归纳、总结方案。基于循证PICOS要素,收集并总结知识图谱常规构建方法。首先,将中成药相关数据实体进行分类,并进行实体链指(消歧);其次,围绕数据实体完成其属性信息的关联和归类;最终,构建实体间的逻辑关系,进而总结得到符合中成药临床证据特点的知识图谱元素关系和延展路径。中成药临床证据知识图谱的构建以流程设计及逻辑结构为主,遵循PICOS原则和证据等级进行知识图谱内元素关系的表达;延展路径跨越3个层级:模式层、数据层应用、新证据应用,具体从疾病、核心评价指标、中成药、核心组方、证治法则、医案对比(演变规律)等逐步探索至新药研发路径。通过该研究,中成药临床证据知识图谱构建的顶层设计已较为明晰,但仍需交叉学科的共同努力,随着符合中医药特色的图谱构建技术的不断完善,将进一步为中医药学科发展提供必要的基础技术支持和借鉴。

This study aims to construct the element relationship and extension path of clinical evidence knowledge map with Chinese patent medicine,providing basic technical support for the formation and transformation of the evidence chain of Chinese patent medicine and providing collection,induction,and summary schemes for massive and disorganized clinical data.Based on the elements of evidence-based PICOS,the conventional construction methods of knowledge graph were collected and summarized.Firstly,the data entities related to Chinese patent medicine were classified,and entity linking was performed(disambiguation).Secondly,the study associated and classified the attribute information of the data entity.Finally,the logical relationship between entities was constructed,and then the element relationship and extension path of the knowledge map conforming to the characteristics of clinical evidence of Chinese patent medicine were summarized.The construction of the clinical evidence knowledge map of Chinese patent medicine was mainly based on process design and logical structure,and the element relationship of the knowledge map was expressed according to the PICOS principle and evidence level.The extension path crossed three levels(model layer,data layer application,and new evidence application),and the study gradually explored the path from disease,core evaluation indicators,Chinese patent medicine,core prescriptions,syndrome and treatment rules,and medical case comparison(evolution law)to new drug research and development.In this study,the top-level design of the construction of the clinical evidence knowledge map of Chinese patent medicine has been clarified,but it still needs the joint efforts of interdisciplinary disciplines.With the continuous improvement of the map construction technology in line with the characteristics of TCM,the study can provide necessary basic technical support and reference for the development of the TCM discipline.