二裂酵母发酵产物溶胞产物复合物的修护功效研究

Study on the repairing efficacy of bifida ferment lysate

采用仿生发酵和无损破壁工艺,从青春双歧杆菌中获得一种二裂酵母发酵产物溶胞产物,通过和甘油,1,2-戊二醇混合后得到原料(BF),分别采用十二烷基硫酸钠(SLS)损伤模型、面部泛红修护模型,通过检测对照组和样品组使用前、使用后皮肤含水量、经表皮失水率(TEWL)、皮肤红度(a*)、皮肤血管密度的变化,对BF修护功效进行研究。结果表明,3%BF处理7天,TEWL值、a*值相比SLS组均呈现显著性下降,且皮下0.2 mm处的血管密度也呈现减少。在面部泛红的受试者人群上,与对照组相比,使用含3%BF的精华乳28天后,皮肤含水量显著上升,TEWL值、a*值均具有显著性下降。因此,BF具有修护功效,且皮肤多光束光学相干性断层扫描系统可从血管密度上辅助评价皮肤红度。

A bifida ferment lysate was obtained from Bifidobacterium adolescentis by biomimetic fermentation and non-destructive wall-breaking technology.It was then mixed with glycerol and 1,2-pentanediol,which was used as a raw material(BF).The repairing efficacy was evaluated according to sodium dodecyl sulfate(SLS)-damaged model and facial redness-repaired model.The changes in skin moisture content,transepidermal water loss(TEWL),skin redness(a*),and skin vascular density before and after treatment were compared between the control group and the sample group.The results showed that,after treatment with 3%BF for 7 days,the TEWL value and a*value were significantly decreased compared with SLS group,and the vascular density at subcutaneous depth of 0.2 mm was also decreased.For the subjects with facial redness,compared with the control group,after using the formula containing 3%BF for 28 days,the skin water content was significantly increased,and the TEWL value and a*value were both significantly decreased.Therefore,BF had repairing efficacy,and skin VivoSight OCT could be used to evaluate skin redness according to vascular density.