皮肤组织常驻记忆T细胞与炎症性皮肤病复发的研究进展

Update of skin tissue-resident memory T cells and inflammatory skin diseases recurrence

组织常驻记忆T细胞(tissue-resident memory T,T_(RM))是一种新发现的记忆T细胞亚群。在皮肤感染(如HSV、白色念珠菌、利什曼原虫感染)及皮肤肿瘤性疾病(如黑素瘤和鳞状细胞癌)中,皮肤T_(RM)细胞发挥保护作用,在部分自身炎性皮肤病中皮肤T_(RM)细胞起致病作用。本文对皮肤T_(RM)细胞与炎症性皮肤病复发的研究进展进行综述,特别是银屑病、白癜风、特应性皮炎、固定性药疹、斑秃和额部纤维性脱发。

Tissue-resident memory T(T_(RM))cells are a newly discovered memory T cell subset.Skin T_(RM)cells play a protective role in skin infections(such as HSV,Candida albicans,and Leishmania infections)and skin neoplastic diseases(such as melanoma and squamous cell carcinoma),and play a pathogeniq role in some autoinflammatory skin diseases.In this paper,we review the update of skin tissue-resident memory T cells and inflammatory skin diseases recurrence,especially psoriasis,vitiligo,atopic dermatitis,fixed drug eruption,alopecia areata and frontal fibrous alopecia.