贝前列腺素纳联合伐地那非对2型糖尿病合并勃起功能障碍患者血清AGEs及AngⅡ水平的影响研究

Effects of beprostaglandin combined with vardenafil on serum levels of AGEs and AngⅡin patients with type 2 diabetes mellitus and erectile dysfunction

目的分析给予2型糖尿病合并勃起功能障碍患者贝前列腺素纳联合伐地那非对其血清晚期糖基化终产物(AGEs)及血管紧张素Ⅱ(AngⅡ)水平的影响。方法从2020年1月至2022年12月在河南中医药大学第一附属医院接受诊治的2型糖尿病合并勃起功能障碍患者中抽取100例作为研究对象,应用随机数字表法分为对照组和观察组,每组50例。两组均给予常规降糖治疗,对照组给予伐地那非进行治疗,观察组在对照组基础上联合贝前列腺素纳治疗。治疗4周后统计两组患者临床疗效,并观察两组治疗前后的勃起硬度评分(EHS)、勃起功能和血清AGEs及AngⅡ水平。结果观察组总有效率高于对照组(P<0.05)。治疗前,两组的EHS评分、ⅡEF-5评分、血清AGEs及AngⅡ水平比较无统计学差异(P>0.05);治疗后,观察组EHS评分和ⅡEF-5评分高于对照组(P<0.05),血清AGEs及AngⅡ水平低于对照组(P<0.05)。结论贝前列腺素纳联合伐地那非对2型糖尿病合并勃起功能障碍患者疗效理想,可有效的增加每周性交成功次数,改善勃起功能障碍,并可有效的调节患者的血清AGEs及AngⅡ水平。

Objective To analyze the effects of beprostaglandin combined with vardenafil on serum levels of advanced glyca⁃tion end products(AGEs)and angiotensinⅡ(AngⅡ)in patients with type 2 diabetes mellitus and erectile dysfunction.Methods From January 2020 to December 2022,100 patients with type 2 diabetes mellitus complicated with erectile dysfunc⁃tion in our hospital were selected as research objects,and were divided into control group and observation group by random number table method,with 50 cases in each group.Both groups were treated with routine hypoglycemic therapy,the control group was treated with vardenafil,and the observation group was treated with beprostaglandin on the basis of the control group.After 4 weeks of treatment,the clinical effects of the two groups were counted,and the erectile stiffness score(EHS),erectile function,serum AGEs and AngⅡlevels were observed before and after treatment.Results The total effective rate of observation group was higher than that of control group(P<0.05).Before treatment,there were no significant differences in EHS scores,ⅡEF-5 scores,serum AGEs and AngⅡlevels between the two groups(P>0.05).After treatment,EHS scores andⅡEF-5 scores in the observation group were higher than those in the control group(P<0.05),and the levels of serum AGEs and AngⅡwere lower than that in the control group(P<0.05).Conclusion Beprostaglandin combined with vardenafil is an ideal therapeutic effect for patients with type 2 diabetes mellitus complicated with erectile dysfunction,which can effec⁃tively increase the number of successful sexual intercourse per week,improve erectile dysfunction,and effectively regulate serum AGEs and AngⅡlevels in patients.