白虎二至汤治疗热盛阴虚型糖尿病肾病Ⅲ期临床观察

Baihu Erzhi Decoction in Treating Stage Ⅲ Diabetic Kidney Disease of Excessive Heat and Yin Deficiency Type

目的 观察白虎二至汤对热盛阴虚型糖尿病肾病(DKD)Ⅲ期患者的临床疗效。方法 将66例DKD患者随机分为对照组和治疗组,各33例。对照组采用缬沙坦胶囊治疗,治疗组在对照组治疗上加用白虎二至汤,观察2组患者空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、尿蛋白/肌酐比(UACR)、尿素氮(BUN)、血肌酐(Scr)以及中医证候积分水平。结果 治疗组有效率显著优于对照组(P<0.05)。治疗后2组患者的2 h PG、HbA1c、UACR、BUN、Scr及中医证候积分水平均低于治疗前(P<0.05),且治疗组均低于对照组(P<0.05)。结论 白虎二至汤可显著改善早期糖尿病肾病患者的临床症状及中医证候,控制血糖水平,改善肾功能,延缓患者疾病进展,提高患者生活质量。

Objective To observe the clinical efficacy of Baihu Erzhi decoction on patients with stage Ⅲ diabetic kidney disease(DKD) of excessive heat and yin deficiency type.Methods Sixty-six patients with DKD were randomly divided into control group and treatment group,with 33 cases in each group.The control group was given valsartan capsules,and the treatment group was treated with Baihu Erzhi decotion on the basis of the conventional basic treatment.Fasting blood glucose(FBG),2 h postprandial blood glucose(2 h PG),glycosylated hemoglobin(HbA1C),urinary albumin/creatinine ratio(UACR),blood urea nitrogen(BUN),serum creatinine(Scr),and TCM syndrome score levels of the patients of the two groups were observed.Results The effective rate of the treatment group was significantly better than that of the control group(P<0.05).After treatment,the levels of 2 h PG,HbA1C,UACR,BUN,Scr and TCM syndrome score in 2 groups were lower than before treatment(P<0.05),and the treatment group was lower than the control group(P<0.05).Conclusion Baihu Erzhi decoction can significantly improve the clinical symptoms and TCM syndromes of early DKD,control blood sugar level,improve renal function,delay disease progression and improve patients' quality of life.