肠道菌群干预肾间质纤维的机制及中药防治研究进展

Mechanism of Intestinal Flora Intervening Renal Interstitial Fiber and Research Progress of Chinese Medicine Prevention

肾间质纤维化(renal interstitial fibrosis,RIF)为慢性肾脏病(chronic kidney disease,CKD)发展成终末期肾脏病的共同病理特征,其发生机制与炎症损伤、氧化应激和细胞自噬等因素密切相关。研究证实肠道菌群与RIF的发生相关,其机制涉及肠道菌群相关的尿毒症毒素、代谢物质等方面。中药在改善RIF进而保护肾功能等方面具有较好的临床效果。大量研究表明中药可以通过调节肠道菌群进而改善RIF。文章就肠道菌群参与RIF的相关机制以及中药调节肠道菌群防治RIF的相应措施做一总结,为后续肠道菌群作为影响RIF提供些许思路和方向。

Renal interstitial fibrosis(RIF)is a common pathological feature of chronic kidney disease(CKD)developing into end-stage renal disease.Its mechanism is closely related to inflammatory injury,oxidative stress and autophagy.Studies have confirmed that intestinal flora is related to the occurrence of RIF,and its mechanism involves uremic toxins and metabolites related to intestinal flora.Traditional Chinese medicine has a good clinical effect in improving RIF and protecting renal function.A large number of studies have shown that Chinese medicine can improve RIF by regulating intestinal flora.This article summarized the related mechanisms of intestinal flora participating in RIF and the corresponding measures of Chinese medicine regulating intestinal flora to prevent and treat RIF,and provided some ideas and directions for subsequent intestinal flora as an impact on RIF.