补阳通栓片治疗气虚血瘀型急性脑梗死的临床效果及机制分析

Clinical effect and mechanism analysis of Buyang Tongshuan tablets in the treatment of acute cerebral infarction of Qi deficiency and blood stasis type

目的探究补阳通栓片治疗气虚血瘀型急性脑梗死(ACI)的临床效果和作用机制。方法采用随机数字表法将146例气虚血瘀型ACI患者分为对照组和观察组,各73例。对照组参照ACI诊治指南进行常规救治,观察组在对照组基础上给予补阳通栓片治疗。比较两组的治疗效果。结果治疗后,观察组的中医证候积分、美国国立卫生研究院卒中量表(NIHSS)评分低于对照组,Barthel指数(BI)评分高于对照组(P<0.05)。观察组的治疗总有效率显著高于对照组(P<0.05)。治疗后,观察组的纤维蛋白原(Fib)、D-二聚体(D-D)水平低于对照组(P<0.05)。治疗后,观察组的脑血管储备功能(CVR)高于对照组,动脉阻力指数(RI)低于对照组(P<0.05)。结论补阳通栓片治疗气虚血瘀型ACI疗效显著,能有效促进患者的神经功能和生活自理能力恢复,这可能与改善机体纤溶-凝血功能、CVR及血流循环等有关。

Objective To explore the clinical effect and mechanism of Buyang Tongshuan tablets in the treatment of acute cerebral infarction(ACI)with Qi deficiency and blood stasis type.Methods A total of 146 ACI patients with Qi deficiency and blood stasis type were divided into control group and observation group by random number table method,with 73 cases in each group.The control group was treated with routine treatment according to the ACI diagnosis and treatment guidelines,and the observation group was treated with Buyang Tongshuan tablets on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the scores of TCM syndromes and National Institutes of Health Stroke Scale(NIHSS)in the observation group were lower than those in the control group,and the Barthel Index(BI)score was higher than that in the control group(P<0.05).The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the levels of fibrinogen(Fib)and D-dimer(D-D)in the observation group were lower than those in the control group(P<0.05).After treatment,the cerebrovascular reserve(CVR)of the observation group was higher than that of the control group,and the arterial resistance index(RI)was lower than that of the control group(P<0.05).Conclusion Buyang Tongshuan tablets have a significant effect on ACI of Qi deficiency and blood stasis type,it can effectively promote the recovery of neurological function and self-care ability of patients,which may be related to the improvement of fibrinolysis-coagulation function,CVR and blood circulation.