维生素D滴剂联合布地奈德气雾剂治疗儿童哮喘的疗效及对患儿肺功能、免疫功能和炎症因子的影响

Efficacy of Vitamin D Drops Combined with Budesonide Aerosol in the Treatment of Children with Asthma and its Effects on Lung Function,Immune Function and Inflammatory Factors in Children with Asthma

目的:探究维生素D滴剂联合布地奈德气雾剂治疗儿童哮喘的疗效及对患儿肺功能、免疫功能和炎症因子的影响。方法:选取2019年8月~2022年12月本院收治的120例哮喘患儿为研究对象,根据治疗方式不同分为观察组和对照组,各60例。对照组予以布地奈德气雾剂治疗;观察组在对照组基础上增加维生素D滴剂治疗。比较两组临床疗效及治疗前后临床症状、肺功能[第1 s用力呼气容积(FEV_(1))、呼气峰流速(PEF)、PEF昼夜变异率]、免疫功能[调节性T细胞(Treg)、辅助性T细胞2(Th2)、Th17]及炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、IL-8]水平。结果:观察组临床总有效率明显高于对照组(91.67%vs73.33%,P<0.05)。与对照组相比,观察组治疗后日间症状、夜间症状评分均更低,C-ACT评分更高(P<0.05)。与对照组相比,观察组治疗后FEV_(1)、PEF、Treg百分比均更高,PEF昼夜变异率、Th2和Th17百分比更低(P<0.05)。治疗后,与对照组相比,观察组TNF-α水平、IL-6水平和IL-8水平均更低(P<0.05)。结论:维生素D滴剂联合布地奈德气雾剂治疗儿童哮喘疗效显著,对患儿临床症状、肺功能均有明显改善作用,提高免疫功能,降低炎症因子水平。

Objective:To explore the efficacy of vitamin D drops combined with budesonide aerosol in the treatment of children with asthma and its effects on lung function,immune function and inflammatory factors.Methods:120 children with asthma admitted to our hospital from August 2019 to December 2022 were randomly divided into observation group and control group,60 cases in each group.The control group was treated with budesonide aerosol;on the basis of the control group,the observation group was treated with vitamin D drops.The clinical efficacy and clinical symptoms,lung function[forced expiratory volume in the first second(FEV_(1)),peak expiratory flow(PEF),PEF diurnal variation rate],immune function[regulatory T cells(Treg),helper T cells 2(Th2),Th17]and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IL-8]levels before and after treatment were compared between the two groups.Results:The total effective rate of the observation group was higher comparing with the control group(91.67%vs 73.33%,P<0.05).Compared with the control group,the scores of daytime symptoms and nighttime symptoms in the observation group were lower,and the C-ACT score was higher(P<0.05).Compared with the control group,the percentage of FEV_(1),PEF and Treg in the observation group was higher,and the diurnal variation rate of PEF,the percentage of Th2 and Th17 were lower(P<0.05).After treatment,the percentages of Treg,Th2 and Th17 in the observation group were lower comparing with the control group(P<0.05).The levels of serum TNF-α,IL-6 and IL-8 in the observation group were significantly lower comparing with the control group(P<0.05).Conclusion:Vitamin D drops combined with budesonide aerosol is effective in the treatment of children with asthma,which can significantly improve the clinical symptoms and lung function,immune function and reduce the level of inflammatory factors.