双歧杆菌三联活菌联合多烯磷脂酰胆碱对乙型肝炎肝硬化代偿期患者肠道菌群和免疫功能的影响

Effects of Live Combined Bifidobacterium,L actobacillus and Enterococcus Combined with Polyene Phosphatidylcholine on Intestinal Flora and Immune Function in Patients with Hepatitis B Virus-Related Compensated Liver Cirrhosis

目的探讨双歧杆菌三联活菌联合多烯磷脂酰胆碱辅助治疗乙型肝炎(简称乙肝)肝硬化代偿期的临床疗效,以及对患者肠道菌群、免疫功能的影响。方法选取沧州市人民医院2020年8月至2022年8月收治的乙肝肝硬化代偿期患者102例,按随机数字表法分为观察组和对照组,各51例。两组患者均予常规治疗,并予多烯磷脂酰胆碱注射液静脉滴注,观察组患者加服双歧杆菌三联活菌胶囊。两组均连续治疗3个月。结果观察组总有效率显著高于对照组(92.16%比74.51%,P<0.05)。两组患者总胆红素、天门冬氨酸氨基转移酶、丙氨酸氨基转移酶及血清层粘连蛋白水平均显著降低(P<0.05),肠道中肠球菌、双歧杆菌、乳酸杆菌、拟杆菌数量均显著增加,酵母样真菌数量均显著减少(P<0.05);T淋巴细胞亚群CD_(4)^(+)、CD_(8)^(+)水平及CD_(4)^(+)/CD_(8)^(+)均改善;且观察组上述指标改善更显著(P<0.05)。结论双歧杆菌三联活菌联合多烯磷脂酰胆碱辅助治疗乙肝肝硬化代偿期,可有效缓解患者的临床症状,纠正肠道菌群失调状态,改善免疫功能,促进肝功能恢复。

Objective To investigate the clinical efficacy of live combined Bifidobacterium,Lactobacillus and Enterococcus combined with polyene phosphatidylcholine in the adjuvant treatment of hepatitis B virus-related compensated liver cirrhosis,and their effects on the patients′intestinal flora and immune function.Methods A total of 102 patients with hepatitis B virus-related compensated liver cirrhosis admitted to the Cangzhou People′s Hospital from August 2020 to August 2022 were selected and divided into the observation group and the control group by the random number table method,with 51 cases in each group.The patients in the two groups were given routine treatment and intravenous drip of Polyene Phosphatidylcholine Injection,on this basis,the patients in the observation group were given Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules,Oral.Both groups were treated continuously for three months.Results The total effective rate in the observation group was significantly higher than that in the control group(92.16%vs.74.51%,P<0.05).After treatment,the total bilirubin(TBiL),aspartate aminotransferase(AST),alanine aminotransferase(ALT)and serum laminin(LN)levels in the two groups were significantly lower(P<0.05),the counts of Enterococcus,Bifidobacterium,Lactobacillus,and Bacteroidetes in the intestine were significantly higher,while that of yeast-like fungi was significantly lower(P<0.05);the T lymphocyte subsets CD_(4)^(+),CD_(8)^(+)levels and CD_(4)^(+)/CD_(8)^(+)in the two groups were better;and the above indexes in the observation group were significantly better(P<0.05).Conclusion Live combined Bifidobacterium,Lactobacillus and Enterococcus combined with polyene phosphatidylcholine in the adjuvant treatment of hepatitis B virus-related compensated liver cirrhosis can effectively relieve the clinical symptoms of patients,regulate the imbalance of intestinal flora,improve immune function,and promote the recovery of liver function.