基于乙癸同源理论探讨左归丸对绝经后骨质疏松症患者骨代谢指标CTRP9、PINP、β-CTX与骨密度的影响

Exploring Effects of Zuogui Pill(左归丸)on Bone Metabolism Indicators CTRP9,PINP and β-CTX and Bone Mineral Density Based on Theory of Yi(Liver)and Gui(Kidney)from Same Source

目的基于“乙癸同源”理论探讨左归丸对绝经后骨质疏松症患者骨代谢指标CTRP9、PINP、β-CTX与骨密度的影响。方法本次研究纳入2018年1月—2021年5月绝经后骨质疏松症女性90例作为观察对象,随机-编号分成2个组,对照组45例采用碳酸钙D3联合阿仑膦酸钠治疗;观察组采用左归丸治疗,持续治疗4周。治疗前后抽取血液标本测定血清β-骨胶原交联(β-CTX)、I型胶原羧基末端肽(PINP)、C1q/TNF相关蛋白9(CTRP9)和腰椎、股骨颈、股骨粗隆的骨密度,同时比较两组的治疗效果和不良反应状况。结果与治疗前比较,两组治疗后血清β-CTX、PINP水平降低,血清CTRP9水平升高;观察组治疗后血清β-CTX、PINP水平低于对照组,血清CTRP9水平高于对照组,相互比较有统计学意义(P<0.05)。与治疗前比较,两组治疗后腰椎、股骨颈、股骨粗隆的骨密度升高;观察组治疗后腰椎、股骨颈、股骨粗隆的骨密度高于对照组,相互比较有统计学意义(P<0.05)。对照组的有效率75.56%低于观察组91.11%,差异有统计学意义(P<0.05)。两组患者的不良反应率比较,无统计学意义(P>0.05)。结论基于“乙癸同源”理论的左归丸对绝经后骨质疏松症患者的治疗效果显著,可以改善骨代谢指标CTRP9、PINP、β-CTX,提高骨密度,而且安全性高,值得大力推广。

Objective To explore the effect of Zuogui Pill(左归丸)on bone metabolism indexes C1q/TNF related protein 9(CTRP9),type I collagen carboxy terminal peptide(PINP)andβ-collagen crosslinking(β-CTX)and bone mineral density.Methods Ninety postmenopausal women with osteoporosis from January 2018 to May 2021 were included,45 cases in the control group were treated with calcium carbonate D3 combined with alendronate sodium,and the observation group was treated with Zuogui Pill for 4 weeks.The serum levels ofβ-CTX,PINP and CTRP9 and bone mineral densities of lumbar spine,femoral neck and femoral trochanter were measured before and after treatment.Methods Compared with those before treatment,the serum levels ofβ-CTX and PINP in both groups after treatment were decreased,while the levels of serum CTRP9 increased.The serum levels ofβ-CTX and PINP in the observation group after treatment were lower than those of the control group,while the serum levels of CTRP9 were higher than those of the control group with statistical significance(P<0.05).Compared with those before treatment,the bone densities of the lumbar spine,femoral neck and femoral trochanter in both groups were increased after treatment.After treatment,the bone densities of the lumbar spine,femoral neck,and femoral trochanter in the observation group were higher than those in the control group with statistical significance(P<0.05).The effective rate(75.56%)in the control group was lower than 91.11%in the observation group,with statistical significance(P<0.05).There was no statistically significant difference in the adverse reaction rates between the two groups of patients(P>0.05).Conclusion Zuogui Pill is effective in the treatment of postmenopausal osteoporosis,and can improve the bone metabolism indexes(CTRP9,PINP andβ-CTX)and the bone mineral density.