夏氏当归止痒方治疗血虚风燥型成人特应性皮炎的疗效观察

Clinical Observation of Xia′s Danggui Zhiyang Recipe(夏氏当归止痒方)in Treatment of Adult Atopic Dermatitis of Blood Deficiency and Wind Dryness Type

目的观察当归止痒方治疗成人血虚风燥型特应性皮炎的临床疗效及安全性。方法2021年7月—2022年1月该院皮肤科就诊的成人特应性皮炎患者中纳入符合血虚风燥证型患者,共76例。随机分入试验组和对照组,每组38例。对照组口服润燥止痒胶囊,试验组口服当归止痒方,两组皆外用纽强倍润型润肤露。治疗8周,对两组瘙痒面积及严重度指数(Eczema Area and Severity Index,EASI)评分、患者主观湿疹评分(Patient-Oriented Eczema Measure,POEM)评分、皮肤病患者生活质量量表(Dermatology Life Quality Index,DLQI)评分、研究者整体评估(Investigator′s Global Assessment,IGA)评分、瘙痒数值评分(Itch-Numerical Rating Scores,Itch-NRS)评分、血清总IgE、血清嗜酸性粒细胞计数(EOS)、中医症状积分及安全性指标等方面进行评价。结果(1)试验组总有效率91.89%(34/37),高于对照组61.76%(21/34)(P<0.05);试验组中医症状积分改善有效率86.49%(32/37),高于对照组47.05%(16/34)(P<0.05)。(2)试验组EASI评分(17.81±6.06)分、POEM评分(11.19±3.76)分、DLQI评分(14.16±3.03)分、IGA评分(2.24±0.68)分、Itch-NRS评分(4.73±1.37)分的下降均较对照组明显(P均<0.05)。(3)两组血清EOS水平在治疗后均有所下降(P<0.05);血清IgE水平两组均无明显干预效果。结论当归止痒方治疗成人血虚风燥型特应性皮炎的临床疗效显著优于润燥止痒胶囊,没有使用首乌的情况下也能够有效改善患者瘙痒症状,提高患者生活质量,同时能够改善患者血虚、便秘、皮肤干燥、瘙痒等中医伴随症状,且没有不良反应发生。

Objective To observe the clinical efficacy and safety of Danggui Zhiyang Recipe(当归止痒方)in treating adult atopic dermatitis due to blood deficiency and wind dryness.Methods From July 2021 to January 2022,76 adult patients with atopic dermatitis who met the syndrome of blood deficiency and wind dryness in the hospital were randomly divided into experimental group and control group,with 38 cases in each group.The control group was treated with Runzao Zhiyang Capsule(润燥止痒胶囊)and the experimental group was treated with Danggui Zhiyang Recipe.Both groups were treated with Niuqiang Beirun Moisturizer.After 8 weeks of treatment,the eczema area and severity index(EASI)score,patient-oriented eczema measure(POEM)score,dermatology life quality index(DLQI)score,investigator′s global assessment(IGA)score,itch-numerical rating scores(Itch-NRS)score,serum total IgE,serum eosinophil count(EOS),TCM symptom score and safety index of the two groups were evaluated.Results After treatment,the total effective rate of the experimental group was 91.89%(34/37),which was higher than that of the control group(61.76%,21/34)(P<0.05).The effective rate of TCM symptom score improvement in the experimental group was 86.49%(32/37),which was higher than that in the control group(47.05%,16/34)(P<0.05).The EASI score[(17.81±6.06)points],the POEM score[(11.19±3.76)points],the DLQI score[(14.16±3.03)points],the IGA score[(2.24±0.68)points]and Itch-NRS score[(4.73±1.37)points]of the experimental group decreased more obviously than those of the control group.The level of serum EOS in both groups decreased after treatment(P<0.05).Serum IgE level had no obvious intervention effect in both groups.Conclusion Danggui Zhiyang Recipe is superior to Runzao Zhiyang Capsule in treating adult atopic dermatitis due to blood deficiency and wind dryness.It can also effectively improve the itching symptoms and the quality of life of patients without using Heshouwu(Polygoni Multiflori Radix).Meanwhile,it can improve the accompanying symptoms of traditional Chinese medicine such as blood deficiency,constipation,dry skin and itching,without adverse reactions.