摘要
肿瘤微环境中存在着许多发挥免疫抑制作用的成分,其中程序性细胞死亡配体-1(PD-L1)与肿瘤相关巨噬细胞(TAMs)关系密切,其在乳腺癌的发生发展中发挥重要作用。本文对PD-L1和TAMs在乳腺癌发生发展中的意义和两者之间可能存在的相互作用机制,以及靶向TAMs在抗程序性细胞死亡受体-1(PD-1)/PD-L1治疗乳腺癌中的影响进行综述。
Tumor microenvironment has many components that play an immunosuppressive role;among which,programmed cell death-ligand 1(PD-L1)is closely related to tumor-associated macrophages(TAMs),and plays a vital role in the occurrence and development of breast cancer.This article reviews the significance of PD-L1 and TAMs in the occurrence and development of breast cancer and the possible interaction mechanism between them,as well as the effects of anti-programmed cell death protein-1(PD-1)/PD-L1 combined with targeting TAMs in the treatment of breast cancer.
作者
陈妙玲
韩玉贞
Chen Miaoling;Han Yuzhen(Department of Pathology,Binzhou Medical University Hospital,Binzhou 256600,China)
出处
《国际医药卫生导报》
2024年第5期732-735,共4页
International Medicine and Health Guidance News
基金
山东省自然科学基金(ZR2010HM096)。
关键词
乳腺癌
PD-L1
肿瘤相关巨噬细胞
免疫抑制
肿瘤微环境
进展
Breast neoplasm
PD-L1
Tumor-associated macrophages
Immunosuppression
Tumor microenvironment
Progress