PD-L1与肿瘤相关巨噬细胞在乳腺癌中的研究进展

Research progress of PD-L1 and tumor-associated macrophages in breast cancer

肿瘤微环境中存在着许多发挥免疫抑制作用的成分,其中程序性细胞死亡配体-1(PD-L1)与肿瘤相关巨噬细胞(TAMs)关系密切,其在乳腺癌的发生发展中发挥重要作用。本文对PD-L1和TAMs在乳腺癌发生发展中的意义和两者之间可能存在的相互作用机制,以及靶向TAMs在抗程序性细胞死亡受体-1(PD-1)/PD-L1治疗乳腺癌中的影响进行综述。

Tumor microenvironment has many components that play an immunosuppressive role;among which,programmed cell death-ligand 1(PD-L1)is closely related to tumor-associated macrophages(TAMs),and plays a vital role in the occurrence and development of breast cancer.This article reviews the significance of PD-L1 and TAMs in the occurrence and development of breast cancer and the possible interaction mechanism between them,as well as the effects of anti-programmed cell death protein-1(PD-1)/PD-L1 combined with targeting TAMs in the treatment of breast cancer.