馥感啉口服液辅助治疗婴幼儿社区获得性肺炎的效果及对患儿肺炎严重程度与免疫功能的影响

Effect of Fuganlin oral liquid in the adjuvant treatment of infants with community-acquired pneumonia and its influence on the severity of pneumonia and immune function

目的探究馥感啉口服液辅助治疗婴幼儿社区获得性肺炎(CAP)的效果及对患儿肺炎严重程度与免疫功能的影响。方法选取2020年9月至2021年9月鹤山市人民医院收治的60例CAP患儿作为研究对象,按照随机数字表法分为观察组与对照组,每组30例。对照组采用抗生素治疗,观察组在对照组基础上采用馥感啉口服液辅助治疗。比较两组临床疗效、低血压和年龄≥65岁(CURB-65)评分、免疫功能指标、临床指标及不良反应发生情况。结果观察组治疗总有效率为93.33%,高于对照组的73.33%,差异有统计学意义(P<0.05)。治疗后第1天,两组CURB-65评分均低于治疗前,差异有统计学意义(P<0.05),但组间比较差异无统计学意义;治疗后第4天,两组CURB-65评分均低于治疗前、治疗后第1天,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组症状改善时间短于对照组,30d内病情复发次数少于对照组,抗生素使用时间长于对照组,差异有统计学意义(P<0.05)。治疗后,观察组IgA、IgM、IgG水平均高于治疗前,且观察组IgA、IgM、IgG水平均高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论与单独使用抗生素治疗相比,馥感啉口服液辅助治疗婴幼儿CAP可更明显降低患儿CURB-65评分,提高其免疫功能,缩短症状改善时间,减少病情复发次数,促进患儿尽快康复,安全性较高。

Objective To explore the effect of Fuganlin oral liquid in the adjuvant treatment of community acquired pneumonia(CAP)in infants and its influence on the severity of pneumonia and immune function.Methods A total of 60 children with CAP diagnosed in Heshan People's Hospi-tal from September 2020 to September 2021 were selected as research subjects,and they were divided into the observation group and the control group according to random number table method,with 30 cases in each group.The control group was treated with antibiotics,and the observation group was treated with fuganline oral liquid on the basis of control group,the clinical efficacy,confusion,urea,respiratory rate,blood pressure,age≥65 years(CURB-65)scores,immune function indexes,clinical indexes and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 93.33%,which was higher than 73.33%in the control group,the difference was statistically signifi-cant(P<0.05).On the 1st d after treatment,the CURB-65 scores of the two groups were lower than before treatment,the difference was statistically significant(P<0.05),but there was no significant difference between groups.On 4th d after treatment,the CURB-65 scores of the two groups were lower than before treatment and 1st d after treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).The symptom improvement time in the observation group was shorter than that in the control group,the recurrence frequency within 30 d was less than that in the control group,and the antibiotic use time was longer than that in the control group,the differences were statisti-cally significant(P<0.05).After treatment,the levels of IgA,IgM and IgG in the observation group were higher than before treatment,and the levels of IgA,IgM and IgG in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Compared with antibiotics alone,fuzhanline oral liquid adjuvant treatment of CAP in infants and young children can significantly reduce the CURB-65 score,improve their immune function,short-en the time for symptom improvement,reduce the number of disease recurrence,and promote the speedy recovery of children,with high safety.