尼可地尔对急性冠脉综合征患者PCI介入治疗后炎性相关指标的影响

Effect of Nicorandil on Inflammation-related Markers after PCI Intervention in Patients with Acute Coronary Syndromes

目的探讨急性冠脉综合征(acute coronary syndrome,ACS)患者经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)后采用尼可地尔治疗后对炎性相关指标的影响,评估其对血管内皮功能的影响。方法将2022年8月至2023年1月于大连医科大学附属第二医院心血管内科行PCI治疗的66例ACS患者作为研究样本,按照完全随机设计法分成对照组和试验组,每组33例。对照组行常规疗法,试验组用尼可地尔治疗。比较2组患者血清中的炎性指标、同型半胱氨酸(hcy)和不良反应情况。结果尼可地尔治疗后,对照组术后炎性相关因子水平高于试验组,差异具有统计学意义(P<0.05);尼可地尔治疗后Hcy水平低于对照组,差异具有统计学意义(P<0.05);试验组不良反应率高于对照组,差异无统计学意义(P>0.05)。结论尼可地尔应用在老年ACS患者PCI术后疗效确切,能优化血管相关炎性指标,降低同型半胱氨酸水平改善冠状动脉血管内皮功能,适合进一步推广。

Objective To investigate the effects of treatment with nicorandil after Percutaneous Coronary Intervention(PCI)in patients with Acute Coronary Syndrome(ACS)on inflammation-related markers,and to assess its effects on vascular endothelial function.Methods Sixty-six ACS patients who underwent PCI in the Department of Cardiovascular Medicine of the Second Affiliated Hospital of Dalian Medical University from August 2022 to January 2023 were used as the study sample,and were divided into the control group and the experimental group according to the method of completely randomized design,with 33 cases in each group.The control group was treated with conventional therapy,and the experimental group was treated with nicorandil.Inflammatory indexes,homocysteine(Hcy)and adverse reactions in serum were compared between the two groups.Results After nicorandil treatment,the levels of postoperative inflammation-related factors in the control group were higher than that in the experimental group,and the difference was statistically significant(P<0.05);The levels of Hcy after nicorandil treatment were lower than that in the control group,and the difference was statistically significant(P<0.05);and the rate of adverse reactions in the experimental group was higher than that in the control group,and there was no statistical difference(P>0.05).Conclusion Nicorandil application in elderly ACS patients after PCI has a definite efficacy,can optimize the vascular-related inflammatory indexes,reduce homocysteine levels to improve coronary vascular endothelial function,and is suitable for further promotion.