糖尿病神经源性膀胱治疗现状

Current status of the treatment for diabetic neurogenic bladder

糖尿病神经源性膀胱(diabetic neurogenic bladder,DNB)是由于糖尿病(diabetesmellitus,DM)患者自主神经,尤其是副交感神经障碍引起膀胱、尿道的储尿、排尿功能失常,产生一系列下尿路症状及并发症的疾病总称,具有发病率高、起病隐匿和发病机制复杂等特点。临床治疗方法繁多,但疗效多不理想,不良反应较多,治疗成本高昂,严重影响患者生活质量。本文从发病机制、药物治疗、非手术治疗和手术治疗四个方面对DNB做一综述,并提出目前治疗的不足与未来研究方向,旨在为DNB的临床诊疗提供一定借鉴与参考。

Diabetic neurogenic bladder(DNB)is a collective term for a series of lower urinary tract symptoms and complications caused by dysfunction of the bladder and urethra in patients with diabetes mellitus(DM),due to autonomic neuropathy,especially parasympathetic nerve dysfunction.It is characterized by a high incidence,insidious onset,and complex pathogenesis.There are numerous clinical treatment methods,but most of them have unsatisfactory efficacy,more adverse reactions,and high treatment costs,which severely impact the patients'quality of life.This article summarizes the pathogenesis,drug treatment,non-surgical treatment,and surgical treatment,and proposes the shortcomings of current treatments and future research directions,aiming to provide a reference for the clinical diagnosis and treatment of DNB.