血清BNP、LCN-2在慢性心力衰竭患者疾病严重程度及预后评价的临床价值

Clinical value of serum BNP and LCN-2 in evaluating disease severity and prognosis of patients with chronic heart failure

目的 探讨血清BNP、LCN-2检测在慢性心衰患者疾病严重程度及预后评价的临床价值。方法 本次研究心衰的患者选取2019年1月至2023年6月在该院实施的90例作为研究组;同时选取同一时期在该院体检且结果显示心脏健康者作为对照组,共纳入90例,对比两组血清BNP、LCN-2检测水平,分析其对急慢性心衰患者严重程度及预后判断的临床价值。结果 观察组LCN-2(89.678±17.48)ng/mL、BNP(2568.11±478.28)pg/mL均高于对照组(60.04±15.31)ng/mL、(196.41±47.49)pg/mL,差异有统计学意义(t=9.782、24.543,P<0.05);观察组随心功能分级升高,BNP及LCN-2水平同步升高,差异有统计学意义(F=19.261、602.689,P<0.05);观察组未发生心血管不良事件76例,发生心血管不良事件14例,发生心血管不良事件患者的BNP及LCN-2水平均显著高于未发生心血管不良事件患者,差异有统计学意义(t=2.218、2.221,P<0.05)。结论 BNP及LCN-2水平变化对于评价慢性心衰患者疾病严重程度及预后有可靠的临床价值,值得推广并应用。

Objective To investigate the clinical value of serum BNP and LCN-2 in evaluating the disease severity and prognosis of patients with chronic heart failure.Methods A total of 90 patients with heart failure who were treated in our hospital from January 2019 to June 2023 were enrolled as observation group,and 90 individuals who underwent cardiac examination in our hospital during the same period of time and had normal results were enrolled as control group.The two groups were compared in terms of the serum levels of BNP and LCN-2,and their clinical value in evaluating the disease severity and prognosis of patients with chronic heart failure was analyzed.Results Compared with the control group,the observation group had significantly higher levels of LCN-2(89.678 ±17.48 ng/mL vs 60.04±15.31 ng/mL,t=9.782,P<0.05) and BNP(2568.11 ±478.28 pg/mL vs 196.41±47.49 pg/mL,t=24.543,P <0.05).In the observation group,the levels of BNP and LCN-2 increased with the increase in cardiac functional grade(F=19.261 and602.689,P <0.05).In the observation group,there were 14 patients with major adverse cardiovascular events and 76without such events,and the patients with major adverse cardiovascular events had significantly higher levels of BNP and LCN-2 than those without such events(t=2.218 and 2.221,P<0.05).Conclusion Changes in the levels of BNP and LCN-2 have a reliable clinical value in evaluating the disease severity and prognosis of patients with chronic heart failure and thus holds promise for clinical application.