辛伐他汀联合N-乙酰半胱氨酸治疗支气管哮喘患者的临床效果

Clinical effect of simvastatin combind with N-acetylcysteine in the treatment of patients with bronchial asthma

目的探讨辛伐他汀联合N-乙酰半胱氨酸治疗支气管哮喘患者的临床效果。方法选取61例支气管哮喘患者作为研究对象,将其随机分为对照组(n=31例)和观察组(n=30例)。对照组给予常规治疗,观察组在对照组的基础上加用辛伐他汀联合N-乙酰半胱氨酸治疗,两组均治疗6周。比较两组患者的临床疗效、治疗前后的肺功能和炎性因子水平,以及治疗期间不良反应的发生情况。结果治疗6周后,观察组患者治疗总有效率高于对照组患者;两组患者呼气峰值流量实测值/预计值、用力肺活量和第1秒用力呼气容积均升高,且观察组患者上述指标均大于对照组患者;两组患者血清白细胞介素-6、白细胞介素-17和肿瘤坏死因子-α水平均降低,且观察组患者上述指标均低于对照组患者(均P<0.05)。治疗期间,两组患者不良反应的发生情况差异无统计学意义(P>0.05)。结论辛伐他汀联合N-乙酰半胱氨酸治疗支气管哮喘患者的临床效果好,可有效地改善患者的肺功能,降低炎性因子水平,减轻气道炎症反应,且不良反应较轻。

Objective To investigate the clinical effect of simvastatin combined with N-acetylcysteine in the treatment of patients with bronchial asthma.Methods A total of 61 patients with bronchial asthma were selected as research subjects and randomly divided into the control group(n=31)or the observation group(n=30).The control group was treated conventionally,based on which the observation group was treated with a combination of simvastatin and N-acetylcysteine additionally,and both groups were treated for 6 weeks.The clinical efficacy,lung function and inflammatory factors levels before and after treatment,and the incidence of adverse reactions during treatment were compared between the two groups.Results After 6 weeks of treatment,the total effective rate of treatment of the observation group was higher than that of the control group;the tested peak expiratory flow over expected,forced vital capacity,and forced expiratory volume in 1 second were increased in both groups,and the above indexes in the observation group were higher than those in the control group;the serum levels of interleukin-6,interleukin-17,and tumor necrosis factor-αin the two groups were decreased,and the above indexes in the observation group were lower than those in the control group(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions during treatment between the two groups(P>0.05).Conclusion Simvastatin combined with N-acetylcysteine has a good clinical effect in the treatment of patients with bronchial asthma,which can effectively improve their lung function,reduce inflammatory factors levels,alleviate airway inflammation,and the adverse reactions are mild.