微RNA在缺氧缺血性脑病中的调控作用研究进展

Research Progress on the Regulatory Role of MicroRNA in Hypoxic Ischemic Encephalopathy

缺氧缺血性脑病(HIE)是一系列由围生期窒息引起的脑部缺氧等病理性损害,可遗留神经系统后遗症,甚至导致新生儿死亡。HIE发病机制复杂,涉及血流重新分配、脑血管自主调节功能障碍、脑组织废弃代谢物堆积等。目前关于HIE临床主要采用对症支持及康复训练治疗。微RNA(miRNA)在转录后调控中发挥重要作用,参与HIE的发生发展,有望成为诊断及监测HIE治疗反应的标志物。因此,深入研究miRNA在HIE中的调控作用,可以为疾病的治疗提供新思路。

Hypoxic ischemic encephalopathy(HIE)is a series of pathological damage caused by perinatal asphyxia in the brain,which can leave a variety of neurological sequelae and even lead to neonatal death.The pathogenesis is complex,including blood flow redistribution,cerebrovascular autonomic regulation dysfunction,and waste metabolite accumulation in brain tissue.At present,the clinical treatment mainly includes symptomatic support and rehabilitation training.MicroRNA(miRNA)play an important role in post-transcriptional regulation,involved in the occurrence and development of HIE,and are expected to become a marker for the diagnosis and monitoring of HIE treatment response.Therefore,in-depth studies of the regulatory role of miRNA in HIE can provide new ideas for the treatment of related diseases.