肠道菌群及代谢物在神经认知恢复延迟中作用的研究进展

Research progress on role of intestinal flora and metabolites in delayed neurocognitive recovery

随着手术和全身麻醉患者数的增加,神经认知恢复延迟的发生率也相应增加,这对患者的生活质量产生了严重影响。微生物-脑-肠轴作为中枢神经系统与肠神经系统的双向通道,越来越引起人们的关注。肠道微生物及其代谢产物不仅在维持肠道内环境稳定方面起着至关重要的作用,而且与神经认知恢复延迟密切相关。目前,对神经认知恢复延迟的治疗尚没有确切的方法,明确肠道菌群及其代谢产物与神经认知恢复延迟的关系可为该疾病的治疗和诊断提供思路和参考。因此,该文针对肠道微生物及其代谢物,分析研究神经认知恢复延迟可能发生和发展的过程。通过深入了解肠道微生物与神经认知恢复延迟的关联,探索其潜在的机制,并为寻找预防和治疗神经认知恢复延迟的方法提供参考。

With the increasing number of surgeries and general anesthesia procedures,the incidence of delayed neurocognitive recovery(DNCR)has also risen,significantly impacting patients'quality of life.The microbiota-gut-brain axis,serving as a bidirectional pathway between the central nervous system and the gut nervous system,has garnered increasing attention.Gut microbiota and their metabolites play crucial roles not only in maintaining intestinal homeostasis but also in closely associating with DNCR.Currently,there is no definitive treatment for DNCR.Clarifying the relationship between gut microbiota and their metabolites with DNCR may provide insights and references for the diagnosis and treatment of this condition.Therefore,this paper analyzes the potential processes underlying the occurrence and development of DNCR concerning gut microbiota and their metabolites.By comprehensively understanding the association between gut microbiota and DNCR,exploring its potential mechanisms,and providing references for finding preventive and therapeutic approaches for DNCR.